Monofunctional and higher-valent platinum anticancer agents.
Monofunctional and higher-valent platinum anticancer agents.
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DOI：
10.1021/ic400538c
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发表时间：
2013-11-04
影响因子：
4.6
通讯作者：
Lippard SJ
中科院分区：
文献类型：
--
作者：
Johnstone TC;Wilson JJ;Lippard SJ
铂化合物代表了金属在医学上的伟大成功故事之一。在Rosenberg偶然发现顺铂的抗癌活性之后，已经制备了大量的顺铂变体，并测试了它们杀死癌细胞和抑制肿瘤生长的能力。这些努力今天仍在继续，人们越来越认识到需要新的策略来克服批准的铂类抗癌药治疗所固有的毒性和耐药性问题。一种方法是使用所谓的“非传统”铂（II）和铂（IV）化合物，这些化合物违反了多年来控制铂药物开发研究的结构-活性关系。另一个是使用专门的药物输送策略。在这里，我们描述了最近的事态发展，从我们的实验室涉及单官能铂（II）配合物连同历史帐户的方式，我们来调查这些化合物和它们的关系，以前研究的分子。我们还讨论了使用铂（IV）前药进行的工作和设计用于在体内递送它们的纳米结构的开发。
Platinum compounds represent one of the great success stories of metals in medicine. Following the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a large number of cisplatin variants have been prepared and tested for their ability to kill cancer cells and inhibit tumor growth. These efforts continue today with increased realization that new strategies are needed to overcome issues of toxicity and resistance inherent to treatment by the approved platinum anticancer agents. One approach has been the use of so-called “non-traditional” platinum(II) and platinum(IV) compounds that violate the structure-activity relationships that governed platinum drug-development research for many years. Another is the use of specialized drug delivery strategies. Here we describe recent developments from our laboratory involving monofunctional platinum(II) complexes together with an historical account of the manner by which we came to investigate these compounds and their relationship to previously studied molecules. We also discuss work carried out using platinum(IV) prodrugs and the development of nanoconstructs designed to deliver them in vivo.
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影响因子：
17.1
作者：
Bhirde, Ashwin A.;Patel, Vyomesh;Gavard, Julie;Zhang, Guofeng;Sousa, Alioscka A.;Masedunskas, Andrius;Leapman, Richard D.;Weigert, Roberto;Gutkind, J. Silvio;Rusling, James F.
通讯作者：
Rusling, James F.
影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
影响因子：
15
作者：
Brown, Sarah D.;Nativo, Paola;Smith, Jo-Ann;Stirling, David;Edwards, Paul R.;Venugopal, Balaji;Flint, David J.;Plumb, Jane A.;Graham, Duncan;Wheate, Nial J.
通讯作者：
Wheate, Nial J.
DOI：
10.1039/dt9910001867
发表时间：
1991-08-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
影响因子：
--
作者：
CAVALLO, L;CINI, R;NATILE, G
通讯作者：
NATILE, G
影响因子：
17.1
作者：
Aryal S;Hu CM;Zhang L
通讯作者：
Zhang L