Mechanisms of interactions between lung-origin telocytes and mesenchymal stem cells to treat experimental acute lung injury.
Mechanisms of interactions between lung-origin telocytes and mesenchymal stem cells to treat experimental acute lung injury.
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肺源性端细胞与间充质干细胞相互作用治疗实验性急性肺损伤的机制。
DOI：
10.1002/ctm2.231
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发表时间：
2020-12
影响因子：
10.6
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Zhang D;Song D;Shi L;Sun X;Zheng Y;Zeng Y;Wang X
急性肺损伤是患者死亡的一种严重形式和主要原因，仍然需要有效的治疗。本研究证明，间充质干细胞（MSCs）和远端细胞（TCs）的共移植改善了实验性肺组织炎症、水肿和损伤的严重程度，其中TCs增加了MSCs向肺的迁移以及MSCs增殖和运动的能力。在分子机制方面，骨桥蛋白优势网络在MSCs和TCs中具有活性，并可能在MSCs和TCs之间的相互作用中发挥支持和营养作用，特别是脂多糖激活的TCs。来自MSCs和TCs的表皮生长因子及其受体之间的相互作用可能在MSCs和TCs之间的通信中发挥关键作用，负责MSCs的增殖和运动，特别是在炎症激活后。我们的研究提供了证据，证明TCs在移植的MSCs中具有营养和支持作用，MSCs和TCs的联合移植可能是治疗急性肺损伤的新选择。TCs可以通过细胞间信号和/或细胞间相互作用加速间充质干细胞从腹腔向受损肺组织的迁移。LPS预处理的MSCs和TCs通过OPN或EGFR主导的信号通路显示出更有效的细胞间通讯
Acute lung injury is a serious form and major cause of patient death and still needs efficient therapies. The present study evidenced that co‐transplantation of mesenchymal stem cells (MSCs) and telocytes (TCs) improved the severity of experimental lung tissue inflammation, edema, and injury, where TCs increased MSCs migration into the lung and the capacity of MSCs proliferation and movement. Of molecular mechanisms, Osteopontin‐dominant networks were active in MSCs and TCs, and might play supportive and nutrimental roles in the interaction between MSCs and TCs, especially activated TCs by lipopolysaccharide. The interaction between epidermal growth factor and its receptor from MSCs and TCs could play critical roles in communications between MSCs and TCs, responsible for MSCs proliferation and movement, especially after inflammatory activation. Our studies provide the evidence that TCs possess nutrimental and supportive roles in implanted MSCs, and co‐transplantation of MSCs and TCs can be a new alternative in the therapy of acute lung injury. TCs can accelerate the migration of MSCs from the intraperitoneal space into injured lung tissues through intercellular signals and/or cell‐cell interaction. Pre‐activated MSCs and TCs with LPS show more efficient in cell‐cell communication by OPN‐ or EGFR‐dominated signal pathways
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