Oxidative Stress during HIV Infection: Mechanisms and Consequences.
Oxidative Stress during HIV Infection: Mechanisms and Consequences.
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DOI：
10.1155/2016/8910396
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发表时间：
2016
影响因子：
--
通讯作者：
Isaguliants MG
中科院分区：
文献类型：
--
作者：
Ivanov AV;Valuev-Elliston VT;Ivanova ON;Kochetkov SN;Starodubova ES;Bartosch B;Isaguliants MG
活性氧（reactive oxygen species，ROS）在细胞内的许多自然过程中起着重要作用。如果增加到不能被防御机制中和的水平，它们会破坏生物分子，改变它们的功能，并且还充当信号分子，从而产生一系列病理。在这篇综述中，我们总结了目前的数据与人类免疫缺陷病毒1型（HIV-1）感染相关的氧化应激标志物，分析这种病毒触发大量ROS生产的机制，并描述了感染的宿主细胞的各种防御机制的状态。此外，我们仔细研究了ROS对HIV-1复制影响的稀缺数据。最后，我们目前的知识状态上的氧化还原改变作为HIV-1致病性的关键因素，如神经毒性和痴呆，耗尽的CD 4 +/CD 8 + T细胞，易患肺部感染，和某些副作用的抗逆转录病毒治疗，并比较它们与亚硝化应激相关的病理。
It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a variety of natural processes in cells. If increased to levels which cannot be neutralized by the defense mechanisms, they damage biological molecules, alter their functions, and also act as signaling molecules thus generating a spectrum of pathologies. In this review, we summarize current data on oxidative stress markers associated with human immunodeficiency virus type-1 (HIV-1) infection, analyze mechanisms by which this virus triggers massive ROS production, and describe the status of various defense mechanisms of the infected host cell. In addition, we have scrutinized scarce data on the effect of ROS on HIV-1 replication. Finally, we present current state of knowledge on the redox alterations as crucial factors of HIV-1 pathogenicity, such as neurotoxicity and dementia, exhaustion of CD4+/CD8+ T-cells, predisposition to lung infections, and certain side effects of the antiretroviral therapy, and compare them to the pathologies associated with the nitrosative stress.
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影响因子：
11.4
作者：
Andrisse, Stanley;Koehler, Rikki M.;Chen, Joseph E.;Patel, Gaytri D.;Vallurupalli, Vivek R.;Ratliff, Benjamin A.;Warren, Daniel E.;Fisher, Jonathan S.
通讯作者：
Fisher, Jonathan S.
DOI：
10.3390/molecules20058742
发表时间：
2015-05-14
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Aoyama K;Nakaki T
通讯作者：
Nakaki T
影响因子：
--
作者：
Ayala A;Muñoz MF;Argüelles S
通讯作者：
Argüelles S
影响因子：
4.4
作者：
Baban, B;Hansen, AM;Mellor, AL
通讯作者：
Mellor, AL
影响因子：
3.7
作者：
Birk J;Ramming T;Odermatt A;Appenzeller-Herzog C
通讯作者：
Appenzeller-Herzog C