Validation of Artificial Intelligence Cardiac MRI Measurements: Relationship to Heart Catheterization and Mortality Prediction.
Validation of Artificial Intelligence Cardiac MRI Measurements: Relationship to Heart Catheterization and Mortality Prediction.
复制标题
人工智能心脏MRI测量的验证：与心脏导管插入术和死亡率预测的关系。
作者：
Cardiac MRI measurements have diagnostic and prognostic value in the evaluation of cardiopulmonary disease. Artificial intelligence approaches to automate cardiac MRI segmentation are emerging but require clinical testing. To develop and evaluate a deep learning tool for quantitative evaluation of cardiac MRI functional studies and assess its use for prognosis in patients suspected of having pulmonary hypertension. A retrospective multicenter and multivendor data set was used to develop a deep learning–based cardiac MRI contouring model using a cohort of patients suspected of having cardiopulmonary disease from multiple pathologic causes. Correlation with same-day right heart catheterization (RHC) and scan-rescan repeatability was assessed in prospectively recruited participants. Prognostic impact was assessed using Cox proportional hazard regression analysis of 3487 patients from the ASPIRE (Assessing the Severity of Pulmonary Hypertension In a Pulmonary Hypertension Referral Centre) registry, including a subset of 920 patients with pulmonary arterial hypertension. The generalizability of the automatic assessment was evaluated in 40 multivendor studies from 32 centers. The training data set included 539 patients (mean age, 54 years ± 20 [SD]; 315 women). Automatic cardiac MRI measurements were better correlated with RHC parameters than were manual measurements, including left ventricular stroke volume (r = 0.72 vs 0.68; P = .03). Interstudy repeatability of cardiac MRI measurements was high for all automatic measurements (intraclass correlation coefficient range, 0.79–0.99) and similarly repeatable to manual measurements (all paired t test P > .05). Automated right ventricle and left ventricle cardiac MRI measurements were associated with mortality in patients suspected of having pulmonary hypertension. An automatic cardiac MRI measurement approach was developed and tested in a large cohort of patients, including a broad spectrum of right ventricular and left ventricular conditions, with internal and external testing. Fully automatic cardiac MRI assessment correlated strongly with invasive hemodynamics, had prognostic value, were highly repeatable, and showed excellent generalizability. Clinical trial registration no. NCT03841344 Published under a CC BY 4.0 license. Online supplemental material is available for this article. See also the editorial by Ambale-Venkatesh and Lima in this issue. An earlier incorrect version appeared online. This article was corrected on June 27, 2022.
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影响因子：
7.5
作者：
Klem, Igor;Shah, Dipan J.;Kim, Raymond J.
通讯作者：
Kim, Raymond J.
影响因子：
14
作者：
Rodriguez-Palomares, Jose F.;Gavara, Jose;Garcia-Dorado, David
通讯作者：
Garcia-Dorado, David
DOI：
10.1186/1532-429x-14-40
发表时间：
2012-06-21
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Swift AJ;Rajaram S;Condliffe R;Capener D;Hurdman J;Elliot CA;Wild JM;Kiely DG
通讯作者：
Kiely DG
影响因子：
5.9
作者：
Alunni, Jean-Philippe;Degano, Bruno;Chabbert, Valerie
通讯作者：
Chabbert, Valerie
DOI：
10.1164/rccm.201611-2365oc
发表时间：
2017-07-15
影响因子：
24.7
作者：
Swift, Andrew J.;Capener, Dave;Kiely, David G.
通讯作者：
Kiely, David G.