Antimalarial drug quality in the most severely malarious parts of Africa - a six country study.
Antimalarial drug quality in the most severely malarious parts of Africa - a six country study.
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DOI：
10.1371/journal.pone.0002132
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发表时间：
2008-05-07
期刊：
影响因子：
3.7
通讯作者：
Attaran, Amir
中科院分区：
文献类型：
--
作者：
Bate, Roger;Coticelli, Philip;Tren, Richard;Attaran, Amir
一系列抗疟疾药物是从六个非洲国家主要城市的城市和城市周边地区的私营药房采购的，这些城市位于非洲大陆和世界疟疾流行最严重的地区。采用半定量薄层层析(TLC)和溶出度测定方法，对照国际认可的标准测定有效药物成分含量。所有测试的样本中有35%没有通过其中一项测试或两项测试都不合格，不合格。此外，收集到的33%是青蒿素单一疗法，其中大多数(78%)是无视世界卫生组织(世卫组织)要求将这些临床上不合适的药物从市场上召回的呼吁而生产的。私营部门的不合格药物和临床上不适当的青蒿素单一疗法的高度持久性危及患者安全，并由于抗药性而使全球疟疾治疗的未来面临风险。
A range of antimalarial drugs were procured from private pharmacies in urban and peri-urban areas in the major cities of six African countries, situated in the part of that continent and the world that is most highly endemic for malaria. Semi-quantitative thin-layer chromatography (TLC) and dissolution testing were used to measure active pharmaceutical ingredient content against internationally acceptable standards. 35% of all samples tested failed either or both tests, and were substandard. Further, 33% of treatments collected were artemisinin monotherapies, most of which (78%) were manufactured in disobservance of an appeal by the World Health Organisation (WHO) to withdraw these clinically inappropriate medicines from the market. The high persistence of substandard drugs and clinically inappropriate artemisinin monotherapies in the private sector risks patient safety and, through drug resistance, places the future of malaria treatment at risk globally.
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作者：
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DOI：
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