Umbilical cord DNA methylation is associated with body mass index trajectories from birth to adolescence.
Umbilical cord DNA methylation is associated with body mass index trajectories from birth to adolescence.
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DOI：
10.1016/j.ebiom.2023.104550
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发表时间：
2023-05
期刊：
影响因子：
11.1
通讯作者：
Liang, Liming
中科院分区：
文献类型：
--
作者：
Meir, Anat Yaskolka;Huang, Wanyu;Cao, Tingyi;Hong, Xiumei;Wang, Guoying;Pearson, Colleen;Adams, William G.;Wang, Xiaobin;Liang, Liming
脐带血中的DNA甲基化（DNAm）与多种产前因素和出生结局相关。本研究旨在填补一个重要的知识空白：脐带血DNAm与儿童从出生到18岁的产后生长轨迹之间的联系。
利用来自美国一个以城市为主、低收入、多种族的出生队列（N = 831）的数据，我们首先应用非参数方法来确定从出生到18岁的体重指数百分位数（BMIPCT）轨迹（作为结果）；然后，对该结果进行全表观基因组关联研究（EWAS），检测由Illumina Infinium MethylationEPIC BeadChip分析的超过70万个CpG位点。应用多元线性回归模型和似然比检验（LRT）来检验整个样本和性别分层中DNAm与结果的关联。
我们确定了四种不同的BMIPCT轨迹模式：正常体重（NW）、早期超重或肥胖（OWO）、晚期OWO以及从正常到极晚期OWO。标注为TPGS1的CpG18582997、TLR7的CpG15241084以及RAB31的cg24350936处的DNAm分别与出生至3岁、10岁和14岁的BMIPCT相关（所有的LRT错误发现率<0.05）。
在这项前瞻性出生队列研究中，我们确定了从出生到18岁的4种不同且稳健的生长轨迹模式，它们与涉及炎症诱导途径的基因的脐带血DNAm变化相关。如果这些发现能进一步得到验证，那么这些DNAm标记以及对BMIPCT轨迹的早期评估可能有助于识别在生命后期有肥胖高风险的幼儿。
详见致谢部分。
DNA methylation (DNAm) in cord blood has been associated with various prenatal factors and birth outcomes. This study sought to fill an important knowledge gap: the link of cord DNAm with child postnatal growth trajectories from birth to age 18 years (y). Using data from a US predominantly urban, low-income, multi-ethnic birth cohort (N = 831), we first applied non-parametric methods to identify body-mass-index percentile (BMIPCT) trajectories from birth to age 18 y (the outcome); then, conducted epigenome-wide association study (EWAS) of the outcome, interrogating over 700,000 CpG sites profiled by the Illumina Infinium MethylationEPIC BeadChip. Multivariate linear regression models and likelihood ratio tests (LRT) were applied to examine the DNAm-outcome association in the overall sample and sex strata. We identified four distinct patterns of BMIPCT trajectories: normal weight (NW), Early overweight or obesity (OWO), Late OWO, and normal to very late OWO. DNAm at CpG18582997 annotated to TPGS1, CpG15241084 of TLR7, and cg24350936 of RAB31 were associated with BMIPCT at birth-to-3 y, 10 y, and 14 y, respectively (LRT FDR < 0.05 for all). In this prospective birth cohort study, we identified 4 distinct and robust patterns of growth trajectories from birth to 18 y, which were associated with variations in cord blood DNAm at genes implicated in inflammation induction pathways. These findings, if further replicated, raise the possibility that these DNAm markers along with early assessment of BMIPCT trajectories may help identify young children at high-risk for obesity later in life. Detailed in the Acknowledgements section.
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影响因子：
14.9
作者：
Buniello, Annalisa;MacArthur, Jacqueline A. L.;Parkinson, Helen
通讯作者：
Parkinson, Helen
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
4.1
作者：
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通讯作者：
Liang L
影响因子：
9.3
作者：
Jornayvaz FR;Vollenweider P;Bochud M;Mooser V;Waeber G;Marques-Vidal P
通讯作者：
Marques-Vidal P
影响因子：
5.8
作者：
Aryee, Martin J.;Jaffe, Andrew E.;Irizarry, Rafael A.
通讯作者：
Irizarry, Rafael A.