Kynurenines with neuroactive and redox properties: relevance to aging and brain diseases.
Kynurenines with neuroactive and redox properties: relevance to aging and brain diseases.
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DOI：
10.1155/2014/646909
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发表时间：
2014
影响因子：
--
通讯作者：
Pérez de la Cruz V
中科院分区：
文献类型：
--
作者：
Reyes Ocampo J;Lugo Huitrón R;González-Esquivel D;Ugalde-Muñiz P;Jiménez-Anguiano A;Pineda B;Pedraza-Chaverri J;Ríos C;Pérez de la Cruz V
犬尿氨酸途径(KP)是色氨酸降解的主要途径，其最终产物为NAD+。色氨酸的代谢会在衰老和神经退化过程中发生变化，导致烟酰胺的生物合成减少。考虑到色氨酸是含有烟酰胺的NAD+辅酶的主要体内储存来源，这一事实非常相关，该辅酶参与了几乎所有的生物能量和生物合成代谢。近年来，研究发现内源性色氨酸及其代谢产物可在组织和细胞内相互作用和/或产生活性氧。由于氧化应激、KP代谢物的改变、能量缺乏、细胞死亡和炎症事件可能相互汇聚，进入反馈循环，其中每个因素相互依赖，从而发挥它们之间的协同作用，因此这一课题非常重要。值得一提的是，所有这些因素都在衰老和神经退行性过程中被描述过；然而，到目前为止，还没有人在KP的变化和这些因素之间建立任何直接的联系。在这篇综述中，我们描述了每个犬尿氨酸的氧化还原性质，它们在实验模型中的作用，它们在老化过程中的变化。
The kynurenine pathway (KP) is the main route of tryptophan degradation whose final product is NAD+. The metabolism of tryptophan can be altered in ageing and with neurodegenerative process, leading to decreased biosynthesis of nicotinamide. This fact is very relevant considering that tryptophan is the major source of body stores of the nicotinamide-containing NAD+ coenzymes, which is involved in almost all the bioenergetic and biosynthetic metabolism. Recently, it has been proposed that endogenous tryptophan and its metabolites can interact and/or produce reactive oxygen species in tissues and cells. This subject is of great importance due to the fact that oxidative stress, alterations in KP metabolites, energetic deficit, cell death, and inflammatory events may converge each other to enter into a feedback cycle where each one depends on the other to exert synergistic actions among them. It is worth mentioning that all these factors have been described in aging and in neurodegenerative processes; however, has so far no one established any direct link between alterations in KP and these factors. In this review, we describe each kynurenine remarking their redox properties, their effects in experimental models, their alterations in the aging process.
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影响因子：
4.4
作者：
Bosco, MC;Rapisarda, A;Varesio, L
通讯作者：
Varesio, L
影响因子：
3.7
作者：
Braidy, Nady;Grant, Ross;Guillemin, Gilles J.
通讯作者：
Guillemin, Gilles J.
DOI：
10.1073/pnas.33.6.155
发表时间：
1947-01-01
影响因子：
11.1
作者：
BEADLE, GW;MITCHELL, HK;NYC, JF
通讯作者：
NYC, JF
影响因子：
14.5
作者：
BLIGHT, AR;COHEN, TI;HEYES, MP
通讯作者：
HEYES, MP
影响因子：
7.3
作者：
Behan, WMH;McDonald, M;Stone, TW
通讯作者：
Stone, TW