MRI-based thermal dosimetry based on single-slice imaging during focused ultrasound thalamotomy.
MRI-based thermal dosimetry based on single-slice imaging during focused ultrasound thalamotomy.
复制标题
聚焦超声丘脑切开术中基于单层成像的磁共振热剂量测定。
DOI：
10.1088/1361-6560/abb7c4
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发表时间：
2020-11-28
影响因子：
3.5
通讯作者：
Rees Cosgrove G
中科院分区：
文献类型：
--
作者：
McDannold N;Jason White P;Rees Cosgrove G
经颅MRI引导聚焦超声（MRgFUS）是一种无创热消融方法，已批准用于治疗原发性震颤和震颤主导型帕金森病。该方法使用MR温度成像（MRTI）来监测治疗。准确跟踪累积的热剂量对于安全性和有效性都很重要。目前，磁共振成像是在一个单一的平面，不同的超声处理，防止直接跟踪的累积剂量。在这项工作中，我们测试了在120 MRgFUS治疗期间估计该剂量的方法。该方法使用磁共振成像创建模拟的热图像超声时，改变成像平面。这种方法准确地预测了病变的形状。器械软件使用的43°C（CEM 43）阈值下17个累积min时病变分割和剂量区域之间的平均Sørensen-Dice相似系数为0.82，但在不同治疗之间存在差异（范围：0.34-0.95）。组织肿胀似乎可以解释什么时候发生不匹配，尽管其他错误可能也有贡献。总体而言，病变分割与17个CEM 43剂量轮廓之间的平均距离为0.37 ± 0.57 mm。在13.6 CEM 43和48.6°C的最高温度下，热损伤概率估计为50%。由于大的热梯度，平均超过99 CEM 43/mm，热损伤概率不确定的区域很窄。总的来说，这些结果表明，17 CEM 43阈值平均而言是热损伤的良好预测因子，尽管总是存在组织命运不确定的狭窄边缘。
Transcranial MRI-guided focused ultrasound (MRgFUS) is a noninvasive thermal ablation method approved for the treatment of essential tremor and tremor-dominant Parkinson’s disease. This method uses MR temperature imaging (MRTI) to monitor the treatment. Accurately tracking the accumulated thermal dose is important for both safety and efficacy. Currently, MRTI is obtained in a single plane that varies between sonications, preventing direct tracking of the accumulated dose. In this work, we tested a method to estimate this dose during 120 MRgFUS treatments. This method used the MRTI to create simulated thermal images for sonications when the imaging plane was changed. This approach accurately predicted the lesion shapes. The mean Sørensen-Dice similarity coefficient between the lesion segmentations and dose regions at the 17 cumulative min at 43°C (CEM43) threshold used by the device software was 0.82 but varied among different treatments (range: 0.34-0.95). Tissue swelling appeared to explain when mismatch occurred, although other errors probably contributed. Overall, the mean distance between the lesion segmentations and the 17 CEM43 dose contours was 0.37 ± 0.57 mm. The probability for thermal damage was estimated to be 50% at 13.6 CEM43 and a maximum temperature of 48.6°C. Due to large thermal gradients, which exceeded 99 CEM43/mm on average, the area where the probability for thermal damage was uncertain was narrow. Overall these results show that the 17 CEM43 threshold is on average a good predictor for thermal lesions, although there will always be a narrow margin where the fate of the tissue is uncertain.
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影响因子：
19.7
作者：
Hynynen, K;Vykhodtseva, NI;Jolesz, FA
通讯作者：
Jolesz, FA
影响因子：
4.1
作者：
Fukutome, Kenji;Kuga, Yoshihiro;Nakase, Hiroyuki
通讯作者：
Nakase, Hiroyuki
影响因子：
3.3
作者：
McDannold, N;Vykhodtseva, N;Hynynen, K
通讯作者：
Hynynen, K
影响因子：
4.1
作者：
Jung, Na Young;Park, Chang Kyu;Chang, Jin Woo
通讯作者：
Chang, Jin Woo
影响因子：
3.1
作者：
Johnson, Sara L.;Dillon, Christopher;Payne, Allison
通讯作者：
Payne, Allison