Oxidative stress and diabetic retinopathy.
Oxidative stress and diabetic retinopathy.
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DOI：
10.1155/2007/43603
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发表时间：
2007
影响因子：
--
通讯作者：
Chan PS
中科院分区：
文献类型：
--
作者：
Kowluru RA;Chan PS
氧代谢对于维持有氧生命是必不可少的，正常的细胞内稳态在活性氧（ROS）的形成和消除之间保持良好的平衡。氧化应激是ROS过度产生和抗氧化防御系统抑制ROS清除的细胞病变结果，与许多疾病的发展有关，包括阿尔茨海默病和糖尿病及其并发症。视网膜病变是糖尿病的一种使人衰弱的微血管并发症，是发达国家获得性失明的主要原因。许多糖尿病诱导的代谢异常与其发展有关，并且似乎受到氧化应激升高的影响;然而，其发展的确切机制仍然难以捉摸。超氧化物浓度的增加被认为是血糖升高与糖尿病并发症发病机制中重要的其他代谢异常之间的因果关系。动物研究表明，抗氧化剂对视网膜病变的发展有有益的影响，但非常有限的临床试验的结果有些模糊。虽然抗氧化剂被用于其他慢性疾病，但有必要进行对照临床试验，以研究抗氧化剂在糖尿病患者视网膜病变发展中的潜在有益作用。
Oxygen metabolism is essential for sustaining aerobic life, and normal cellular homeostasis works on a fine balance between the formation and elimination of reactive oxygen species (ROS). Oxidative stress, a cytopathic consequence of excessive production of ROS and the suppression of ROS removal by antioxidant defense system, is implicated in the development of many diseases, including Alzheimer's disease, and diabetes and its complications. Retinopathy, a debilitating microvascular complication of diabetes, is the leading cause of acquired blindness in developed countries. Many diabetes-induced metabolic abnormalities are implicated in its development, and appear to be influenced by elevated oxidative stress; however the exact mechanism of its development remains elusive. Increased superoxide concentration is considered as a causal link between elevated glucose and the other metabolic abnormalities important in the pathogenesis of diabetic complications. Animal studies have shown that antioxidants have beneficial effects on the development of retinopathy, but the results from very limited clinical trials are somewhat ambiguous. Although antioxidants are being used for other chronic diseases, controlled clinical trials are warranted to investigate potential beneficial effects of antioxidants in the development of retinopathy in diabetic patients.
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影响因子：
3.4
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
2003-01-20
影响因子：
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作者：
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通讯作者：
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