Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K.
Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K.
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DOI：
10.1021/acs.analchem.1c00716
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发表时间：
2021-06-22
影响因子：
7.4
通讯作者：
Chekmenev EY
中科院分区：
文献类型：
--
作者：
Chapman B;Joalland B;Meersman C;Ettedgui J;Swenson RE;Krishna MC;Nikolaou P;Kovtunov KV;Salnikov OG;Koptyug IV;Gemeinhardt ME;Goodson BM;Shchepin RV;Chekmenev EY
我们报告一个强大的和低成本的仲氢发生器设计采用液氮作为冷却剂。发生器的核心由催化剂填充的螺旋铜管组成，可以加压到35个大气压。在77 K下，使用顺磁性水合氧化铁催化剂，用三个几乎相同的发生器获得仲氢分数>48%。通过台式NMR光谱法实时进行仲氢定量，以监测来自NMR沉默的残留正氢-仲氢的信号。该实时定量方法也用于评价在高达1.0标准升/分钟流速下的催化剂活化。报道的廉价设备可以用于广泛的研究，采用仲氢作为核自旋超极化的来源。为此，我们证明了这种仲氢发生器的实用性，用于超极化浓缩的[1- 13 C]丙酮酸钠，代谢造影剂在许多临床试验中的调查。报告的SABRE-SHEATH超极化的试验性优化在1 T的临床相关磁场下产生了超过14，000倍的13 C信号增强，对应于约1.2%的13 C极化-如果使用接近100%的仲氢，则报告的值将增加两倍，达到3.5%的13 C极化。
We report on a robust and low-cost parahydrogen generator design employing liquid nitrogen as coolant. The core of the generator consists of catalyst-filled spiral copper tubing, which can be pressurized to 35 atm. Parahydrogen fraction >48% was obtained at 77 K with three nearly identical generators using paramagnetic hydrated iron oxide catalyst. Parahydrogen quantification was performed on the fly via bench-top NMR spectroscopy to monitor the signal from residual orthohydrogen—parahydrogen is NMR silent. This real-time quantification approach was also used to evaluate catalyst activation at up to 1.0 standard liter per minute flow rate. The reported inexpensive device can be employed for a wide range of studies employing parahydrogen as a source of nuclear spin hyperpolarization. To this end, we demonstrate the utility of this parahydrogen generator for hyperpolarization of concentrated sodium [1-13C]pyruvate, a metabolic contrast agent under investigation in numerous clinical trials. The reported pilot optimization of SABRE-SHEATH hyperpolarization yielded 13C signal enhancement of over 14,000-fold at clinical relevant magnetic field of 1 T corresponding to approximately 1.2% 13C polarization – if near 100% parahydrogen would have been employed, the reported value would be tripled to 13C polarization of 3.5%.
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影响因子：
2.2
作者：
Baer, Sebastien;Lange, Thomas;Hoevener, Jan-Bernd
通讯作者：
Hoevener, Jan-Bernd
影响因子：
3.3
作者：
Fekete, Marianna;Ahwal, Fadi;Duckett, Simon B.
通讯作者：
Duckett, Simon B.
DOI：
10.1007/s10334-005-0007-x
发表时间：
2005-11-01
影响因子：
2.3
作者：
Bhattacharya, P;Harris, K;Ross, BD
通讯作者：
Ross, BD
影响因子：
15
作者：
Emmett, PH;Harkness, RW
通讯作者：
Harkness, RW
影响因子：
2.1
作者：
Das, Taraknath;Kweon, Soon-Cheol;Oh, In-Hwan
通讯作者：
Oh, In-Hwan