Sleep quality and preclinical Alzheimer disease.
Sleep quality and preclinical Alzheimer disease.
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睡眠质量和临床前阿尔茨海默氏病。
DOI：
10.1001/jamaneurol.2013.2334
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发表时间：
2013-05
期刊：
影响因子：
29
通讯作者：
Holtzman, David M.
中科院分区：
文献类型：
--
作者：
Ju, Yo-El S.;McLeland, Jennifer S.;Toedebusch, Cristina D.;Xiong, Chengjie;Fagan, Anne M.;Duntley, Stephen P.;Morris, John C.;Holtzman, David M.
睡眠和昼夜节律问题在阿尔茨海默病（AD）中非常常见。最近的动物研究表明，睡眠和淀粉样蛋白-β（Aβ）之间存在双向关系，A β是参与AD发病机制的关键分子。本研究测试了在出现认知障碍之前，临床前AD中的Aβ沉积是否与睡眠质量或数量的变化相关。认知正常的中年人（n=142）使用体动仪客观测量睡眠2周。同时睡眠日记提供午睡信息。脑脊液Aβ42水平用于确定是否存在淀粉样蛋白沉积。睡眠参数与淀粉样蛋白沉积有关。与没有淀粉样蛋白沉积的人相比，淀粉样蛋白沉积与更差的睡眠质量相关，特别是更差的睡眠效率（睡眠时间百分比）。相比之下，通过总睡眠时间测量，各组之间的睡眠量没有差异。频繁小睡与淀粉样蛋白沉积有关。AD临床前阶段的淀粉样蛋白沉积似乎与较差的睡眠质量相关，但与睡眠量的变化无关。
Sleep and circadian problems are very common in Alzheimer Disease (AD). Recent animal studies suggest a bidirectional relationship between sleep and amyloid-β (Aβ), a key molecule involved in AD pathogenesis. This study tested whether Aβ deposition in preclinical AD, prior to the appearance of cognitive impairment, is associated with changes in quality or quantity of sleep. Cognitively normal, middle-aged individuals (n=142) had sleep objectively measured using actigraphy for 2 weeks. Concurrent sleep diaries provided nap information. Cerebrospinal fluid Aβ42 levels were used to determine whether amyloid deposition was present or absent. Sleep parameters were assessed with regard to amyloid deposition. Amyloid deposition was associated with worse sleep quality, specifically worse sleep efficiency (% time in bed that was spent asleep), compared to those without amyloid deposition. In contrast, quantity of sleep was not different between groups, as measured by total sleep time. Frequent napping was associated with amyloid deposition. Amyloid deposition in the preclinical stage of AD appears to be associated with worse sleep quality, but not with changes in sleep quantity.
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影响因子：
4.8
作者：
Keage, Hannah Amy Dianne;Banks, Siobhan;Matthews, Fiona Elaine
通讯作者：
Matthews, Fiona Elaine
DOI：
10.1126/science.1180962
发表时间：
2009-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
19.9
作者：
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通讯作者：
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影响因子：
17.1
作者：
Roh JH;Huang Y;Bero AW;Kasten T;Stewart FR;Bateman RJ;Holtzman DM
通讯作者：
Holtzman DM