Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain.
Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain.
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DOI：
10.1016/j.neuroimage.2020.116704
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发表时间：
2020-07-01
期刊：
影响因子：
5.7
通讯作者：
Yendiki A
中科院分区：
文献类型：
--
作者：
Jones R;Grisot G;Augustinack J;Magnain C;Boas DA;Fischl B;Wang H;Yendiki A
在第一项研究中，我们比较了高角分辨率扩散MRI（dMRI）在人脑中的轴突方向测量偏振敏感光学相干断层扫描（PSOCT），我们比较了各种dMRI采样方案和重建方法的方向估计的准确性。我们发现，如果仔细选择重建方法，单壳dMRI数据可以产生相同的精度作为多壳数据，只有适度低于一个完整的笛卡尔网格采样方案的准确性。我们的研究结果表明，目前的dMRI重建方法并没有从超高的b值或非常大量的扩散编码方向中获益。我们还表明，在1 mm或更小的dMRI体素尺寸范围内，准确度保持稳定，但在2 mm时会降低，特别是在复杂的白质结构区域。我们还表明，随着空间分辨率的降低，dMRI体素中的轴突配置无法再建模为一小组不同的轴突群，这违反了dMRI重建技术有时做出的假设。我们的研究结果在体内研究的影响，并说明了PSOCT的价值作为一个来源，不遭受典型的组织学技术的扭曲的白质组织的地面实况测量。
In the first study comparing high angular resolution diffusion MRI (dMRI) in the human brain to axonal orientation measurements from polarization-sensitive optical coherence tomography (PSOCT), we compare the accuracy of orientation estimates from various dMRI sampling schemes and reconstruction methods. We find that, if the reconstruction approach is chosen carefully, single-shell dMRI data can yield the same accuracy as multi-shell data, and only moderately lower accuracy than a full Cartesian-grid sampling scheme. Our results suggest that current dMRI reconstruction approaches do not benefit substantially from ultra-high b-values or from very large numbers of diffusion-encoding directions. We also show that accuracy remains stable across dMRI voxel sizes of 1 mm or smaller but degrades at 2 mm, particularly in areas of complex white-matter architecture. We also show that, as the spatial resolution is reduced, axonal configurations in a dMRI voxel can no longer be modeled as a small set of distinct axon populations, violating an assumption that is sometimes made by dMRI reconstruction techniques. Our findings have implications for in vivo studies and illustrate the value of PSOCT as a source of ground-truth measurements of white-matter organization that does not suffer from the distortions typical of histological techniques.
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影响因子：
5.7
作者：
Khan AR;Cornea A;Leigland LA;Kohama SG;Jespersen SN;Kroenke CD
通讯作者：
Kroenke CD
影响因子：
3.3
作者：
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5.3
作者：
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