Elevated Soluble Fas and FasL in Cerebrospinal Fluid and Serum of Patients With Anti-N-methyl-D-aspartate Receptor Encephalitis.
Elevated Soluble Fas and FasL in Cerebrospinal Fluid and Serum of Patients With Anti-N-methyl-D-aspartate Receptor Encephalitis.
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DOI：
10.3389/fneur.2018.00904
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发表时间：
2018
影响因子：
3.4
通讯作者：
Wang HH
中科院分区：
文献类型：
--
作者：
Ding YW;Pan SY;Xie W;Shen HY;Wang HH
目的：抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎是一种严重的自身免疫性疾病，主要累及儿童和年轻女性。Fas系统包括膜结合型Fas（mFas）和Fas配体（mFasL），以及可溶性Fas和sFasL，它们在细胞凋亡和免疫调节中起重要作用。sFas和sFasL的水平及其在抗NMDAR疾病发病机制中的作用仍不清楚。研究方法：收集抗NMDAR脑炎、其他原因脑炎和周围神经病患者的48对脑脊液（CSF）和血清。采用酶联免疫吸附法（ELISA）测定脑脊液（CSF）和血清中sFas和sFasL的浓度。结果：抗NMDAR脑炎患者脑脊液中sFas和sFasL浓度均高于对照组。抗NMDAR脑炎患者血清sFas水平也相对于对照升高。CSF中sFas和sFasL浓度与发病时和6个月随访时的改良兰金量表（mRS）呈正相关。结论：抗NMDAR脑炎患者脑脊液sFas和sFasL水平升高，可反映抗NMDAR脑炎的病情严重程度。
Objective: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune disorder that mainly affects children and young women. The Fas system contains both membrane-bound versions of Fas (mFas) and Fas ligand (mFasL), and soluble versions (sFas and sFasL), which play important roles in apoptosis and regulation of the immune system. Both the levels of sFas and sFasL and the role they play in anti-NMDAR disease pathogenesis remain unclear. Methods: Forty-eight pairs of cerebrospinal fluid (CSF) and serum were collected from patients with anti-NMDAR encephalitis, encephalitis of other causes or peripheral neuropathy. The CSF and serum concentrations of sFas and sFasL were determined with enzyme-linked immunosorbent assay. Results: CSF concentrations of sFas and sFasL were both increased in anti-NMDAR encephalitis patients compared with controls patients. Serum sFas levels were also elevated in anti-NMDAR encephalitis patients relative to controls. sFas and sFasL concentrations in CSF positively correlated with the modified Rankin scale (mRS) both at onset and 6-months follow-up. Conclusion: CSF sFas and sFasL levels were elevated in anti-NMDAR encephalitis patients, and reflect the disease severity of anti-NMDAR encephalitis.
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影响因子：
5.2
作者：
Felderhoff-Mueser, U;Herold, R;Bührer, C
通讯作者：
Bührer, C
DOI：
10.4049/jimmunol.182.3.1469
发表时间：
2009-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Strauss L;Bergmann C;Whiteside TL
通讯作者：
Whiteside TL
影响因子：
14.5
作者：
Kreye, Jakob;Wenke, Nina K.;Pruss, Harald
通讯作者：
Pruss, Harald
影响因子：
14.5
作者：
Bien, Christian G.;Vincent, Angela;Bauer, Jan
通讯作者：
Bauer, Jan
DOI：
10.1016/s1474-4422(15)00401-9
发表时间：
2016-04
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Graus F;Titulaer MJ;Balu R;Benseler S;Bien CG;Cellucci T;Cortese I;Dale RC;Gelfand JM;Geschwind M;Glaser CA;Honnorat J;Höftberger R;Iizuka T;Irani SR;Lancaster E;Leypoldt F;Prüss H;Rae-Grant A;Reindl M;Rosenfeld MR;Rostásy K;Saiz A;Venkatesan A;Vincent A;Wandinger KP;Waters P;Dalmau J
通讯作者：
Dalmau J