Cortical reactivity and effective connectivity during REM sleep in humans.

Cortical reactivity and effective connectivity during REM sleep in humans.
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DOI:
10.1080/17588921003731578
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发表时间:
2010-09
影响因子:
2
通讯作者:
Tononi G
Tononi G
中科院分区:
医学4区
文献类型:
--
作者:
Massimini M;Ferrarelli F;Murphy M;Huber R;Riedner B;Casarotto S;Tononi G

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我们记录了夜间第一次快速眼动(REM)睡眠时经颅磁刺激(TMS)诱发的脑电(EEG)反应,并将其与之前清醒和NREM睡眠时的反应进行了比较。证实了之前的发现,在进入NREM睡眠时,皮质激活变得更加局部性和刻板印象,表明皮质内对话显著受损。在REM睡眠期间,受试者恢复意识但几乎瘫痪,TMS触发了更广泛和不同的皮质激活模式,类似于清醒时观察到的模式。同样,TMS/HD-EEG可能被用来探测无法移动和交流的脑损伤患者丘脑皮质系统的内部对话。
We recorded the electroencephalographic (EEG) responses evoked by transcranial magnetic stimulation (TMS) during the first rapid eye movement (REM) sleep episode of the night and we compared them with the responses obtained during previous wakefulness and NREM sleep. Confirming previous findings, upon falling into NREM sleep, cortical activations became more local and stereotypical, indicating a significant impairment of the intracortical dialogue. During REM sleep, a state in which subjects regain consciousness but are almost paralyzed, TMS triggered more widespread and differentiated patterns of cortical activation, that were similar to the ones observed in wakefulness. Similarly, TMS/hd-EEG may be used to probe the internal dialogue of the thalamocortical system in brain injured patients that are unable to move and communicate.
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