The effect of long-term diethylstilbestrol treatment or hyperprolactinemia on the response of the tuberoinfundibular dopamine neurons to elevated prolactin
The effect of long-term diethylstilbestrol treatment or hyperprolactinemia on the response of the tuberoinfundibular dopamine neurons to elevated prolactin
复制标题
长期己烯雌酚治疗或高催乳素血症对结节漏斗部多巴胺神经元对催乳素升高反应的影响
DOI：
10.1016/0006-8993(85)90487-1
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发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
D. Herbert
中科院分区：
文献类型：
--
作者：
W. W. Morgan;A. Bartke;D. Herbert
用两种不同的方法使成年雄性大鼠出现高泌乳素血症。一些动物皮下植入己烯雌酚（DES）或空胶囊。2个月后取出胶囊。其他大鼠在肾包膜下接受3次垂体前叶同种移植物或假手术。des处理的大鼠在去除胶囊后8个月死亡，而垂体移植的大鼠在手术后4或12个月死亡。des处理大鼠垂体前叶增生，des处理大鼠和垂体前叶同种移植物大鼠均出现高泌乳素血症。与各自的对照组相比，这两个实验组的大鼠的TIDA神经元的活性明显升高，正如正中隆起（ME）中多巴胺（DA）合成所证明的那样。这些数据：(1)表明DES停药后8个月垂体增生的维持并非由于TIDA神经元功能受损；(2)没有证据表明长时间高泌乳素血症对TIDA神经元对PRL升高的反应有神经毒性作用。
Adult male rats were rendered hyperprolactinemic by two different methods. Some animals received subcutaneous implants of diethylstilbestrol (DES) or empty capsules. After 2 months the capsules were removed. Other rats received 3 anterior pituitary homografts under the kidney capsule or had sham surgery. The DES-treated rats were killed 8 months after capsule removal, while pituitary-grafted rats were killed 4 or 12 months after surgery. The DES-treated rats had hyperplastic anterior pituitaries, and both the DES-treated rats and the rats with anterior pituitary homografts were hyperprolactinemic. The activity of the TIDA neurons, as evidenced by dopamine (DA) synthesis in the median eminence (ME), was markedly and comparably elevated in both of these experimental groups of rats when compared to their respective controls. These data: (1) show that the maintenance of hyperplastic pituitaries 8 months after DES withdrawal is not due to impaired function of the TIDA neurons; and (2) provide no evidence for a neurotoxic effect of prolonged hyperprolactinemia on the response of the TIDA neurons to elevated PRL.
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影响因子：
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影响因子：
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影响因子：
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影响因子：
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作者：
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影响因子：
4.1
作者：
Bartke,A;Doherty,PC;Steger,RW;Morgan,WW;Amador,AG;Herbert,DC;Siler-Khodr,TM;Smith,MS;Klemcke,HG;Hymer,WC
通讯作者：
Hymer,WC