Unexplained immunodeficiency in children: a surveillance report.
Unexplained immunodeficiency in children: a surveillance report.
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儿童不明原因的免疫缺陷：监测报告。
DOI：
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
D. Auerbach
中科院分区：
文献类型：
--
作者：
P. Thomas;H. Jaffe;T. Spira;R. Reiss;Guerrero Ic;D. Auerbach
从1982年10月1日到1983年10月1日，疾病控制中心(CDC)收到了35名儿童的报告，他们的疾病符合CDC对获得性免疫缺陷综合征(AIDS)的定义。所有的儿童都有严重的机会性感染，没有已知的潜在疾病来解释感染的易感性。这35名儿童来自十个不同的州；病例集中在五个主要大都市地区。其中三名儿童的父母患有艾滋病，此前被报道的一名儿童接受了一名后来患上艾滋病的人的输血。在成人艾滋病病例发生的人群中，大多数儿童的父母至少有一人。许多儿童有前驱症状的病史，包括肺炎、淋巴结病、肝肿大和口腔鹅口疮。平均发病年龄为5个月，确诊时平均年龄为12个月。为了确定在没有潜在免疫缺陷的儿童中机会性感染是否真的是一种新现象，对向疾病预防控制中心提出的药物异硫代戊二胺的请求进行了审查。这表明从1979年到1983年，在没有已知潜在免疫缺陷的儿童中，卡氏肺孢子虫肺炎明显增加。(JAMA1984；252：639-644)
From Oct 1, 1982, to Oct 1, 1983, the Centers for Disease Control (CDC) received reports of 35 children whose illness met the CDC definition of acquired immune deficiency syndrome (AIDS). All of the children had serious opportunistic infections without a known underlying illness to explain susceptibility to the infections. The 35 children were residents of ten different states; cases clustered in five major metropolitan areas. Three of the children had a parent with AIDS, and one child who had been previously reported had received a blood transfusion from a person in whom AIDS later developed. Most of the children had at least one parent in a population group in which adult AIDS cases have occurred. Many of the children had histories of prodromal symptoms, including pneumonitis, lymphadenopathy, hepatomegaly, and oral thrush. The mean age at onset of illness was 5 months, and the mean age at diagnosis was 12 months. To determine whether opportunistic infection in children without underlying immunodeficiency was truly a new phenomenon, a review of requests to the CDC for the drug pentamidine isethionate was undertaken. This revealed an apparent increase from 1979 to 1983 inPneumocystis cariniipneumonia in children without known underlying immunodeficiency. (JAMA1984;252:639-644)
性乱和吸毒成瘾的母亲所生婴儿患有 T4/T8 比例逆转的获得性免疫缺陷。
DOI：
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发表时间：
1983
期刊：
JAMA : the journal of the American Medical Association
影响因子：
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作者：
Rubinstein,A;Sicklick,M;Gupta,A;Bernstein,L;Klein,N;Rubinstein,E;Spigland,I;Fruchter,L;Litman,N;Lee,H;Hollander,M
通讯作者：
Hollander,M
DOI：
10.1016/0002-9343(82)90174-7
发表时间：
1982
期刊：
The American journal of medicine
影响因子：
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作者：
Stahl,RE;Friedman-Kien,A;Dubin,R;Marmor,M;Zolla-Pazner,S
通讯作者：
Zolla-Pazner,S
患有获得性免疫缺陷综合症的男性女性性伴侣的免疫缺陷。
DOI：
10.1056/nejm198305193082001
发表时间：
1983
期刊：
The New England journal of medicine
影响因子：
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作者：
Harris,C;Small,CB;Klein,RS;Friedland,GH;Moll,B;Emeson,EE;Spigland,I;Steigbigel,NH
通讯作者：
Steigbigel,NH