The effects of axial displacement on fracture callus morphology and MSC homing depend on the timing of application.
The effects of axial displacement on fracture callus morphology and MSC homing depend on the timing of application.
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DOI：
10.1016/j.bone.2010.03.008
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发表时间：
2010-07
期刊：
影响因子：
4.1
通讯作者：
Goldstein, Steven A.
中科院分区：
文献类型：
--
作者：
Weaver, Aaron S.;Su, Yu-Ping;Begun, Dana L.;Miller, Joshua D.;Alford, Andrea I.;Goldstein, Steven A.
局部力学环境和间充质干细胞（MSCs）的可获得性都已被证明是骨折愈合的重要因素。本研究旨在探讨在骨折愈合过程中施加轴向位移的时机如何影响骨痂特性以及系统性引入的间充质干细胞的迁移。在雄性Sprague - Dawley大鼠中制造双侧截骨。通过尾静脉注射外源性间充质干细胞，并在手术后0、3、10或24天开始对一个缺损部位施加可控的微动。结果显示，术后10天受到刺激的骨折在48天时比其他组有更多的矿物质、更少的软骨以及更好的力学性能。在术后48天，除了术后10天受到刺激的那组外，在截骨部位都发现了间充质干细胞群。这些结果表明，力学刺激的时机影响骨痂的物理特性以及间充质干细胞向骨折部位的迁移。
The local mechanical environment and the availability of mesenchymal stem cells (MSCs) have both been shown to be important factors in bone fracture healing. This study was designed to investigate how the timing of an applied axial displacement across a healing fracture affects callus properties as well as the migration of systemically introduced MSCs. Bilateral osteotomies were created in male, Sprague-Dawley rats. Exogenous MSCs were injected via the tail vein, and a controlled micro-motion was applied to one defect starting 0, 3, 10, or 24 days after surgery. The results showed that fractures stimulated 10 days after surgery had more mineral, less cartilage, and greater mechanical properties at 48 days than other groups. Populations of MSCs were found in osteotomies 48 days after surgery, with the exception of the group that was stimulated 10 days after surgery. These results demonstrate that the timing of mechanical stimulation affects the physical properties of the callus and the migration of MSCs to the fracture site.
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影响因子：
2.8
作者：
HOLBEIN, O;NEIDLINGERWILKE, C;CLAES, L
通讯作者：
CLAES, L
DOI：
10.1073/pnas.92.11.4857
发表时间：
1995-05-23
影响因子：
11.1
作者：
PEREIRA, RF;HALFORD, KW;PROCKOP, DJ
通讯作者：
PROCKOP, DJ
影响因子：
2.6
作者：
Devine, SM;Bartholomew, AM;Hoffman, R
通讯作者：
Hoffman, R
DOI：
10.2106/00004623-199072090-00016
发表时间：
1990-10-01
影响因子：
5.3
作者：
EINHORN, TA;SIMON, G;VIGORITA, VJ
通讯作者：
VIGORITA, VJ
影响因子：
4.4
作者：
Chen, JL;Li, Y;Chopp, M
通讯作者：
Chopp, M