Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown.
Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown.
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DOI：
10.1371/journal.pone.0098439
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Kilgard MP
中科院分区：
文献类型：
--
作者：
Centanni TM;Chen F;Booker AM;Engineer CT;Sloan AM;Rennaker RL;LoTurco JJ;Kilgard MP
在子宫内，大鼠阅读障碍相关基因KIAA0319(KIA-)的RNAi降低了大脑对语音的反应，并增加了开始潜伏期的逐个试验的可变性。我们测试了KIA大鼠在言语声音辨别方面会受到损害的假设。起亚-大鼠需要在安静条件下进行两倍的训练才能达到对照水平，并在几项言语任务中保持受损。使用截断语音的集中训练能够使安静和背景噪声条件下的语音辨别正常化。训练还使逐个试验的神经变异性和时间相位锁定正常化。受过语言训练的KIA大鼠的大脑皮质活动足以准确区分相似的辅音。这些结果提供了第一个直接的证据，表明假设阅读障碍相关基因KIAA0319的表达减少可以导致类似于阅读障碍的音素处理障碍，并且强化行为疗法可以消除这些障碍。
In utero RNAi of the dyslexia-associated gene Kiaa0319 in rats (KIA-) degrades cortical responses to speech sounds and increases trial-by-trial variability in onset latency. We tested the hypothesis that KIA- rats would be impaired at speech sound discrimination. KIA- rats needed twice as much training in quiet conditions to perform at control levels and remained impaired at several speech tasks. Focused training using truncated speech sounds was able to normalize speech discrimination in quiet and background noise conditions. Training also normalized trial-by-trial neural variability and temporal phase locking. Cortical activity from speech trained KIA- rats was sufficient to accurately discriminate between similar consonant sounds. These results provide the first direct evidence that assumed reduced expression of the dyslexia-associated gene KIAA0319 can cause phoneme processing impairments similar to those seen in dyslexia and that intensive behavioral therapy can eliminate these impairments.
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影响因子：
3.7
作者：
Adler WT;Platt MP;Mehlhorn AJ;Haight JL;Currier TA;Etchegaray MA;Galaburda AM;Rosen GD
通讯作者：
Rosen GD
影响因子：
4.5
作者：
Dennis MY;Paracchini S;Scerri TS;Prokunina-Olsson L;Knight JC;Wade-Martins R;Coggill P;Beck S;Green ED;Monaco AP
通讯作者：
Monaco AP
影响因子：
16.2
作者：
Chandrasekaran, Bharath;Hornickel, Jane;Skoe, Erika;Nicol, Trent;Kraus, Nina
通讯作者：
Kraus, Nina
影响因子：
9.8
作者：
Cope, N;Harold, D;Williams, J
通讯作者：
Williams, J
影响因子：
2.5
作者：
Doron, NN;Ledoux, JE;Semple, MN
通讯作者：
Semple, MN