Divergent Mast Cell Responses Modulate Antiviral Immunity During Influenza Virus Infection.
Divergent Mast Cell Responses Modulate Antiviral Immunity During Influenza Virus Infection.
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不同的肥大细胞反应调节流感病毒感染期间的抗病毒免疫力
DOI：
10.3389/fcimb.2021.580679
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发表时间：
2021
影响因子：
5.7
通讯作者：
Paust S
中科院分区：
文献类型：
--
作者：
Murphy-Schafer AR;Paust S
甲型流感病毒（IAV）是一种呼吸道病原体，每年感染数百万人。季节性和大流行性IAV毒株都能引起严重的呼吸道疾病，具有呼吸衰竭和机会性继发感染的高风险。强烈的炎性细胞因子反应是严重IAV感染的标志。严重流感期间肺中广泛的组织损伤和水肿主要归因于炎性细胞因子的过度产生以及驻留和浸润白细胞的细胞杀伤。肥大细胞（MC）是位于包括肺在内的粘膜部位的前哨造血细胞类型。MCs在检测到感染后立即做出反应，产生大量的免疫调节分子，包括炎性细胞因子，趋化因子和蛋白酶。因此，MC被认为是在严重流感中观察到的免疫病理学的来源。然而，越来越多的证据表明，MC不仅在诱导炎症反应中起重要作用，而且在抑制炎症反应中也起重要作用。MC衍生的免疫抑制细胞因子对于许多病毒感染和其他免疫损伤的解决是必不可少的。MC的缺乏会导致感染，加重组织损伤，并有助于病原体向其他组织的传播。MC产生细胞因子如IL-10和IL-6对于减轻由先天性和适应性免疫细胞引起的炎症和组织损伤是必不可少的。MCs的两种相反的功能-一种促炎和一种抗炎-将MCs区分为感染部位免疫的主要调节剂。在对感染或损伤作出反应的第一批细胞中，MC在感染期间持续存在，调节其他免疫细胞的募集、激活和最终抑制。在这篇综述中，我们将讨论MC在病毒感染过程中的免疫调节作用，并提出由MC产生的免疫抑制介质是至关重要的，以尽量减少流感感染期间的免疫病理学。
Influenza A virus (IAV) is a respiratory pathogen that infects millions of people each year. Both seasonal and pandemic strains of IAV are capable of causing severe respiratory disease with a high risk of respiratory failure and opportunistic secondary infection. A strong inflammatory cytokine response is a hallmark of severe IAV infection. The widespread tissue damage and edema in the lung during severe influenza is largely attributed to an overexuberant production of inflammatory cytokines and cell killing by resident and infiltrating leukocytes. Mast cells (MCs) are a sentinel hematopoietic cell type situated at mucosal sites, including the lung. Poised to react immediately upon detecting infection, MCs produce a vast array of immune modulating molecules, including inflammatory cytokines, chemokines, and proteases. As such, MCs have been implicated as a source of the immunopathology observed in severe influenza. However, a growing body of evidence indicates that MCs play an essential role not only in inducing an inflammatory response but in suppressing inflammation as well. MC-derived immune suppressive cytokines are essential to the resolution of a number of viral infections and other immune insults. Absence of MCs prolongs infection, exacerbates tissue damage, and contributes to dissemination of the pathogen to other tissues. Production of cytokines such as IL-10 and IL-6 by MCs is essential for mitigating the inflammation and tissue damage caused by innate and adaptive immune cells alike. The two opposing functions of MCs—one pro-inflammatory and one anti-inflammatory—distinguish MCs as master regulators of immunity at the site of infection. Amongst the first cells to respond to infection or injury, MCs persist for the duration of the infection, modulating the recruitment, activation, and eventual suppression of other immune cells. In this review, we will discuss the immune modulatory roles of MCs over the course of viral infection and propose that the immune suppressive mediators produced by MCs are vital to minimizing immunopathology during influenza infection.
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影响因子：
--
作者：
Caughey, George H.
通讯作者：
Caughey, George H.
影响因子：
4.4
作者：
Chen, Mei-Chun;Lin, Chiou-Feng;Lin, Yee-Shin
通讯作者：
Lin, Yee-Shin
DOI：
10.1038/nri2782
发表时间：
2010-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.1
作者：
BARTON, BE;JACKSON, JV
通讯作者：
JACKSON, JV
支气管上皮细胞中的流感H5N1和H1N1病毒复制和先天免疫反应受分化状态的影响。
影响因子：
3.7
作者：
Chan RW;Yuen KM;Yu WC;Ho CC;Nicholls JM;Peiris JS;Chan MC
通讯作者：
Chan MC