hOGG1 promoter methylation, hOGG1 genetic variants and their interactions for risk of coal-borne arsenicosis: A case-control study.
hOGG1 promoter methylation, hOGG1 genetic variants and their interactions for risk of coal-borne arsenicosis: A case-control study.
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hOGG1 启动子甲基化、hOGG1 遗传变异及其与煤源性砷中毒风险的相互作用：病例对照研究。
DOI：
10.1016/j.etap.2020.103330
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发表时间：
2020-01
影响因子：
4.3
通讯作者：
Aihua Zhang
中科院分区：
文献类型：
--
作者：
Lu Ma;Bing Liang;Yuan Yang;Liyuan Chen;Qizhan Liu;Aihua Zhang
为探讨hOGG 1甲基化、Ser 326 Cys多态性及其交互作用对煤源性砷中毒发病风险的影响，收集了113例煤源性砷中毒患者和55例正常对照。采用ICP-MS分析尿砷含量，甲基化特异性PCR和限制性片段长度多态性PCR分别检测PBLC中hOGG 1甲基化和Ser 326 Cys多态性。结果表明，随着砷中毒患者尿砷水平的升高，hOGG 1基因甲基化率和变异基因型（326 Ser/Cys和326 Cys/Cys）的发生率均增高。甲基化hOGG1.1的流行率增加和变异基因型与砷中毒的风险增加有关。此外，研究结果还表明，变异基因型可能会增加hOGG 1甲基化的易感性。甲基化hOGG 1.和变异基因型的相互作用也被发现有助于砷中毒的风险增加。hOGG 1基因甲基化、hOGG 1基因变异及其相互作用可能是评价煤源性砷中毒风险的潜在生物标志物。
To identify the effect of hOGG1 methylation, Ser326Cys polymorphism and their interactions on the risk of coalborne.arsenicosis, 113 coal-borne arsenicosis subjects and 55 reference subjects were recruited. Urinary arsenic.contents were analyzed with ICP-MS. hOGG1 methylation and Ser326Cys polymorphism was measured by.mehtylation-specific PCR and restriction fragment length polymorphism PCR in PBLCs, respectively. The results.showed that the prevalence of methylated hOGG1 and variation genotype (326 Ser/Cys & 326 Cys/Cys) were increased.with raised levels of urinary arsenic in arsenicosis subjects. Increased prevalence of methylated hOGG1.and variation genotype were associated with raised risk of arsenicosis. Moreover, the results revealed that.variant genotype might increase the susceptibility to hOGG1 methylation. The interactions of methylated hOGG1.and variation genotype were also found to contribute to increased risk of arsenicosis. Taken together, hOGG1.hypermethylation, hOGG1 variants and their interactions might be potential biomarkers for evaluating risk of.coal-borne arsenicosis.
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影响因子：
--
作者：
Qin H;Zhu J;Zeng Y;Du W;Shen D;Lei Z;Qian Q;Huang JA;Liu Z
通讯作者：
Liu Z
影响因子：
3
作者：
K. Rehman;Fiza Fatima;M. Akash
通讯作者：
K. Rehman;Fiza Fatima;M. Akash
DOI：
10.1016/j.jtemb.2019.04.009
发表时间：
2019-07
期刊：
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
影响因子：
--
作者：
Kyi Mar Wai;M. Umezaki;Ohn Mar;Mitsutoshi Umemura;C. Watanabe
通讯作者：
Kyi Mar Wai;M. Umezaki;Ohn Mar;Mitsutoshi Umemura;C. Watanabe
DOI：
10.1186/s12940-017-0283-8
发表时间：
2017-07-18
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Kibriya MG;Jasmine F;Parvez F;Argos M;Roy S;Paul-Brutus R;Islam T;Ahmed A;Rakibuz-Zaman M;Shinkle J;Slavkovich V;Graziano JH;Ahsan H
通讯作者：
Ahsan H
影响因子：
7.5
作者：
Hawkins, Nicholas J.;Lee, James H-F;Hitchins, Megan P.
通讯作者：
Hitchins, Megan P.