The Impact of Serial Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation and Brain Injury Related Biomarkers.
The Impact of Serial Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation and Brain Injury Related Biomarkers.
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DOI：
10.3389/fphys.2022.835173
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发表时间：
2022
影响因子：
4
通讯作者：
Guo ZN
中科院分区：
文献类型：
--
作者：
Qu Y;Zhang P;He QY;Sun YY;Wang MQ;Liu J;Zhang PD;Yang Y;Guo ZN
近年来的研究表明，远程缺血处理（RIC）在脑血管病患者中具有积极的作用，但其机制尚不清楚。本研究旨在探讨连续RIC对脑血管病患者动态脑自动调节功能（dCA）及脑损伤相关血清生物标志物的影响，二者均与脑血管病的预后有关。这是一项在健康成人中进行的自我对照干预性研究。RIC每天进行两次，连续7天（d1-d7），包括在200 mmHg下进行4 × 5分钟的单臂袖带充气/放气循环。所有受试者均接受了10次dCA评估，包括基线、研究的d1、d2、d4、d7、d8、d10、d14、d21和d35。在dCA测量后立即采集4次血样（基线、d1、d7和d8）。传递函数参数[相位差（PD）和增益]用于量化dCA。检测了与脑损伤相关的四种血清生物标志物，泛素C末端水解酶-L1、神经元特异性烯醇化酶、胶质细胞酸性蛋白和S100 β。本研究入组了22例健康成人志愿者（平均年龄25.73 ± 1.78岁，3例男性[13.6%]，均为亚洲人）。与基线PD值相比，完成4次RIC后（d2）双侧PD值显著更高（左侧：53.31 ± 10.53 vs. 45.87 ± 13.02度，p = 0.015;右侧：54.90 ± 10.46 vs. 45.96 ± 10.77度，p = 0.005）。在完成7天的RIC后，dCA的显著增加持续至少28天（d35，左侧：53.11 ± 14.51度，P = 0.038;右侧：56.95 ± 14.57度，P <0.001）。RIC前后与脑损伤相关的不同血清生物标志物无差异。在4次重复RIC后立即检测到dCA升高，连续7天的RIC诱导dCA持续增加至少28天，并且不影响健康成人脑损伤的血液生物标志物。这些结果将有助于我们制定详细的策略，安全有效地应用RIC在脑血管疾病患者。
Recent studies have demonstrated the positive roles of remote ischemic conditioning (RIC) in patients with cerebrovascular diseases; however, the mechanisms remain unclear. This study aimed to explore the effect of serial RIC on dynamic cerebral autoregulation (dCA) and serum biomarkers associated with brain injury, both of which are related to the prognosis of cerebrovascular disease. This was a self-controlled interventional study in healthy adults. The RIC was conducted twice a day for 7 consecutive days (d1–d7) and comprised 4 × 5-min single arm cuff inflation/deflation cycles at 200 mmHg. All participants underwent assessments of dCA ten times, including baseline, d1, d2, d4, d7, d8, d10, d14, d21, and d35 of the study. Blood samples were collected four times (baseline, d1, d7, and d8) immediately after dCA measurements. The transfer function parameters [phase difference (PD) and gain] were used to quantify dCA. Four serum biomarkers associated with brain injury, ubiquitin C-terminal hydrolase-L1, neuron-specific enolase, glial fibrillary acidic protein, and S100β were tested. Twenty-two healthy adult volunteers (mean age 25.73 ± 1.78 years, 3 men [13.6%], all Asian) were enrolled in this study. Bilateral PD values were significantly higher since four times of RIC were completed (d2) compared with PD values at baseline (left: 53.31 ± 10.53 vs. 45.87 ± 13.02 degree, p = 0.015; right: 54.90 ± 10.46 vs. 45.96 ± 10.77 degree, p = 0.005). After completing 7 days of RIC, the significant increase in dCA was sustained for at least 28 days (d35, left: 53.11 ± 14.51 degree, P = 0.038; right: 56.95 ± 14.57 degree, p < 0.001). No difference was found in terms of different serum biomarkers related to brain injury before and after RIC. The elevation in dCA was detected immediately after four repeated times of RIC, and 7-day consecutive RIC induced a sustained increase in dCA for at least 28 days and did not affect blood biomarkers of brain injury in healthy adults. These results will help us to formulate detailed strategies for the safe and effective application of RIC in patients with cerebrovascular disease.
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DOI：
10.1186/2040-7378-2-2
发表时间：
2010-01-21
期刊：
Experimental & translational stroke medicine
影响因子：
--
作者：
Durukan A;Tatlisumak T
通讯作者：
Tatlisumak T
影响因子：
7.4
作者：
Guo W;Ren C;Zhang B;Zhao W;Gao Y;Yu W;Ji X
通讯作者：
Ji X
影响因子：
9.9
作者：
An, Jia-qi;Cheng, Ya-wen;Luo, Guo-gang
通讯作者：
Luo, Guo-gang
影响因子：
48
作者：
Bazarian, Jeffrey J.;Biberthaler, Peter;Jagoda, Andy S.
通讯作者：
Jagoda, Andy S.
影响因子：
3.2
作者：
Jones, Helen;Hopkins, Nicola;Thijssen, Dick H. J.
通讯作者：
Thijssen, Dick H. J.