Diabetes mellitus type II as a risk factor for depression: a lower than expected risk in a general practice setting.
Diabetes mellitus type II as a risk factor for depression: a lower than expected risk in a general practice setting.
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DOI：
10.1007/s10654-009-9385-0
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发表时间：
2009
影响因子：
13.6
通讯作者：
Metsemakers, J. F. M.
中科院分区：
文献类型：
--
作者：
Aarts, S.;van den Akker, M.;van Boxtel, M. P. J.;Jolles, J.;Winkens, B.;Metsemakers, J. F. M.
本研究的目的是确定糖尿病（DM）的诊断是否与原发性抑郁症的风险增加有关。采用基于注册网络家庭实践（RNH）数据库的回顾性队列设计。将在1980年1月1日至2007年1月1日期间诊断为糖尿病的40岁或40岁以后的患者（N = 6，140）与来自无糖尿病史的参考组（N = 18，416）的年龄匹配对照进行比较。两组患者均接受首次诊断为抑郁症（和/或抑郁情绪）的随访，直至2008年1月1日。被诊断患有糖尿病的人中有2.0%发展为抑郁症，而对照组为1.6%。在对混杂因素进行统计学校正后，糖尿病与随后发生抑郁（HR 1.26; 95% CI：1.12-1.42）和/或抑郁感（HR 1.33; 95% CI：1.18-1.46）的风险增加相关。经统计学调整后，实践识别码、年龄和糖尿病前抑郁症与抑郁症的诊断有显著相关。糖尿病患者比没有糖尿病史的人更容易发展为随后的抑郁症。基于全科医学人群的大型纵向研究结果表明，这种关联比以前使用自我报告调查的横断面研究中发现的要弱。几种解释这种差异进行了讨论。
The aim of the present study was to determine whether a diagnosis of diabetes mellitus (DM) in a primary setting is associated with an increased risk of subsequent depression. A retrospective cohort design was used based on the Registration Network Family Practice (RNH) database. Patients diagnosed with diabetes mellitus at or after the age of 40 and who were diagnosed between 01-01-1980 and 01-01-2007 (N = 6,140), were compared with age-matched controls from a reference group (N = 18,416) without a history of diabetes. Both groups were followed for an emerging first diagnosis of depression (and/or depressive feelings) until January 1, 2008. 2.0% of the people diagnosed with diabetes mellitus developed a depressive disorder, compared to 1.6% of the reference group. After statistical correction for confounding factors diabetes mellitus was associated with an increased risk of developing subsequent depression (HR 1.26; 95% CI: 1.12–1.42) and/or depressive feelings (HR 1.33; 95% CI: 1.18–1.46). After statistical adjustment practice identification code, age and depression preceding diabetes, were significantly related to a diagnosis of depression. Patients with diabetes mellitus are more likely to develop subsequent depression than persons without a history of diabetes. Results from this large longitudinal study based on a general practice population indicate that this association is weaker than previously found in cross-sectional research using self-report surveys. Several explanations for this dissimilarity are discussed.
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影响因子：
6.3
作者：
CROMBIE, DL;CROSS, KW;FLEMING, DM
通讯作者：
FLEMING, DM
影响因子：
--
作者：
Maraldi, Cinzia;Volpato, Stefano;Pahor, Marco
通讯作者：
Pahor, Marco
影响因子：
7.2
作者：
van den Akker, M;Buntinx, F;Knottnerus, JA
通讯作者：
Knottnerus, JA
影响因子：
5.1
作者：
Kessing, LV;Nilsson, FM;Andersen, PK
通讯作者：
Andersen, PK
影响因子：
8
作者：
Petrak, F;Hardt, J;Hoffmann, SO
通讯作者：
Hoffmann, SO