Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting.
Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting.
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DOI：
10.3390/vaccines4030028
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发表时间：
2016-08-06
期刊：
影响因子：
7.8
通讯作者：
Elkord E
中科院分区：
文献类型：
--
作者：
Chaudhary B;Elkord E
近年来，人们在理解和调节癌症免疫反应方面做出了重大努力。在这种情况下，免疫抑制细胞，包括调节性T细胞（TCFs）和骨髓源性抑制细胞（MDSC），已经受到了激烈的研究，他们提出的作用，抑制肿瘤特异性免疫反应和建立免疫抑制肿瘤微环境，从而使肿瘤免疫逃避。此外，最近的证据表明，TcB包括不同的和异质的子集;肿瘤浸润性TcB的表型和功能不同的子集可能对癌症预后和临床结果有不同的贡献。了解癌症背景下的Treg生物学，特别是肿瘤微环境，对于设计有效的癌症疗法非常重要。在这篇综述中，我们批判性地研究了TdR在肿瘤微环境和癌症进展中的作用，重点是人类研究。我们还讨论了目前治疗方式对Treg生物学的影响，以及靶向Treg以增强抗肿瘤免疫应答和临床益处的治疗机会。
Recent years have seen significant efforts in understanding and modulating the immune response in cancer. In this context, immunosuppressive cells, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), have come under intense investigation for their proposed roles in suppressing tumor-specific immune responses and establishing an immunosuppressive tumor microenvironment, thus enabling tumor immune evasion. Additionally, recent evidence indicates that Tregs comprise diverse and heterogeneous subsets; phenotypically and functionally distinct subsets of tumor-infiltrating Tregs could contribute differently to cancer prognosis and clinical outcomes. Understanding Treg biology in the setting of cancer, and specifically the tumor microenvironment, is important for designing effective cancer therapies. In this review, we critically examine the role of Tregs in the tumor microenvironment and in cancer progression focusing on human studies. We also discuss the impact of current therapeutic modalities on Treg biology and the therapeutic opportunities for targeting Tregs to enhance anti-tumor immune responses and clinical benefits.
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影响因子：
--
作者：
Elkord E;Abd Al Samid M;Chaudhary B
通讯作者：
Chaudhary B
影响因子：
24.5
作者：
Betts G;Jones E;Junaid S;El-Shanawany T;Scurr M;Mizen P;Kumar M;Jones S;Rees B;Williams G;Gallimore A;Godkin A
通讯作者：
Godkin A
影响因子：
11.5
作者：
Bergmann, Christoph;Strauss, Laura;Whiteside, Theresa L.
通讯作者：
Whiteside, Theresa L.
影响因子：
20.3
作者：
Duhen, Thomas;Duhen, Rebekka;Campbell, Daniel J.
通讯作者：
Campbell, Daniel J.
影响因子：
20.3
作者：
Dong, Shen;Maiella, Sylvie;Rogge, Lars
通讯作者：
Rogge, Lars