Acute allograft rejection: cellular and humoral processes.
Acute allograft rejection: cellular and humoral processes.
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DOI:
10.1016/j.ccm.2011.02.008
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发表时间:
2011-06
影响因子:
5.7
通讯作者:
Palmer SM
中科院分区:
文献类型:
--
作者:
Martinu T;Pavlisko EN;Chen DF;Palmer SM
Acute cellular rejection affects greater than one-third of lung transplant recipients. Alloreactive T-lymphocytes constitute the basis of lung allograft rejection. Recent evidence supports a more complex immune response to the allograft. Interaction between recipient genetics, immunosuppression therapies, and allograft environmental exposures likely contribute to high rejection rates after lung transplantation. A greater understanding of the heterogeneous mechanisms of lung rejection is critical to developing effective therapies that target the precise pathophysiology of the disease and ultimately improve long-term lung transplant outcomes.
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