Acute allograft rejection: cellular and humoral processes.

Acute allograft rejection: cellular and humoral processes.
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DOI:
10.1016/j.ccm.2011.02.008
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发表时间:
2011-06
影响因子:
5.7
通讯作者:
Palmer SM
Palmer SM
中科院分区:
医学3区
文献类型:
--
作者:
Martinu T;Pavlisko EN;Chen DF;Palmer SM

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急性细胞排斥影响超过三分之一的肺移植受者。同种异体t淋巴细胞是肺移植排斥反应的基础。最近的证据支持对同种异体移植物的更复杂的免疫反应。受体遗传学、免疫抑制疗法和同种异体移植环境暴露之间的相互作用可能导致肺移植后的高排异率。更好地了解肺排斥反应的异质性机制对于开发针对该疾病的精确病理生理的有效疗法并最终改善长期肺移植结果至关重要。
Acute cellular rejection affects greater than one-third of lung transplant recipients. Alloreactive T-lymphocytes constitute the basis of lung allograft rejection. Recent evidence supports a more complex immune response to the allograft. Interaction between recipient genetics, immunosuppression therapies, and allograft environmental exposures likely contribute to high rejection rates after lung transplantation. A greater understanding of the heterogeneous mechanisms of lung rejection is critical to developing effective therapies that target the precise pathophysiology of the disease and ultimately improve long-term lung transplant outcomes.
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