Syndecan-4 as a Marker of Endothelial Dysfunction in Patients with Resistant Hypertension.
Syndecan-4 as a Marker of Endothelial Dysfunction in Patients with Resistant Hypertension.
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DOI：
10.3390/jcm9093051
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发表时间：
2020-09-22
影响因子：
3.9
通讯作者：
Wallbach M
中科院分区：
文献类型：
--
作者：
Lipphardt M;Dihazi H;Maas JH;Schäfer AK;Amlaz SI;Ratliff BB;Koziolek MJ;Wallbach M
(1)背景：动脉高血压（HTN）是最相关的心血管危险因素之一。如今，多种药物治疗选择与新的介入方法（例如，压力反射激活疗法（BAT））作为治疗耐药HTN患者的最后手段。虽然耐药HTN背后的病理生理学仍然没有完全理解。有证据表明，选定的生物标志物可能参与HTN的病理生理学。(2)方法：我们调查了BAT植入前和植入后6个月耐药HTN患者的血清SDC 4-水平。我们从耐药HTN和血压高于目标的患者中收集了19份血液样本，并测量了血清SDC 4-水平。(3)结果：我们的研究结果显示，与健康人群相比，耐药HTN患者的血清SDC 4水平较高。耐药HTN和II型糖尿病患者的血清SDC 4水平较高。β受体阻滞剂对血清SDC 4水平有降低作用，而钙通道阻滞剂与血清SDC 4水平升高相关。BAT植入治疗6个月后，血清SDC 4水平没有显著差异。(4)结论：根据我们的研究结果，我们提出SDC 4在耐药HTN患者中升高。因此，SDC 4可能是顽固性高血压患者内皮功能障碍的潜在标志物。
(1) Background: Arterial hypertension (HTN) is one of the most relevant cardiovascular risk factors. Nowadays multiple pharmaceutical treatment options exist with novel interventional methods (e.g., baroreflex activation therapy (BAT)) as a last resort to treat patients with resistant HTN. Although pathophysiology behind resistant HTN is still not fully understood. There is evidence that selected biomarkers may be involved in the pathophysiology of HTN. (2) Methods: We investigated serum SDC4-levels in patients suffering from resistant HTN before and 6 months after BAT implantation. We collected 19 blood samples from patients with resistant HTN and blood pressure above target and measured serum SDC4-levels. (3) Results: Our results showed high serum SDC4-levels in patients with resistant HTN as compared to a healthy population. Patients with both, resistant HTN and diabetes mellitus type II, demonstrated higher serum SDC4-levels. β-blockers had lowering effects on serum SDC4-levels, whereas calcium channel blockers were associated with higher levels of serum SDC4. BAT implantation did not lead to a significant difference in serum SDC4-levels after 6 months of therapy. (4) Conclusion: Based on our results we propose SDC4 is elevated in patients suffering from resistant HTN. Thus, SDC4 might be a potential marker for endothelial dysfunction in patients with resistant hypertension.
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影响因子：
5.8
作者：
Fang, Yun;Wu, David;Birukov, Konstantin G.
通讯作者：
Birukov, Konstantin G.
自主性封锁会逆转与肥胖相关的高血压中的内皮功能障碍。
DOI：
10.1161/hypertensionaha.116.07681
发表时间：
2016-10
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Gamboa A;Figueroa R;Paranjape SY;Farley G;Diedrich A;Biaggioni I
通讯作者：
Biaggioni I
DOI：
10.1016/j.bbamcr.2015.07.011
发表时间：
2015-10-01
影响因子：
5.1
作者：
Kim, Eun Young;Roshanravan, Hila;Dryer, Stuart E.
通讯作者：
Dryer, Stuart E.
影响因子：
3.5
作者：
Grassi, Guido;Seravalle, Gino;Mancia, Giuseppe
通讯作者：
Mancia, Giuseppe
影响因子：
2.7
作者：
de la Sierra, A.;Larrousse, M.
通讯作者：
Larrousse, M.