Study of Long-Term Biocompatibility and Bio-Safety of Implantable Nanogenerators.
Study of Long-Term Biocompatibility and Bio-Safety of Implantable Nanogenerators.
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DOI：
10.1016/j.nanoen.2018.07.008
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发表时间：
2018-09
期刊：
影响因子：
17.6
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Li J;Kang L;Yu Y;Long Y;Jeffery JJ;Cai W;Wang X
植入式纳米发电机 (i-NG) 在实现自供电植入式医疗设备 (IMD) 方面展现出了巨大的前景。 i-NG实际应用的一项基本要求是其长期的生物相容性和生物安全性。本文介绍了一项将聚二甲基硅氧烷 (PDMS) 和 PDMS/聚对二甲苯-C 包装的聚偏二氟乙烯 (PVDF) NG 植入雌性 ICR（癌症研究所）小鼠体内长达六个月的系统研究。 PVDF NG 在弯曲 7200 次循环时具有 0.3 V 的稳定体外输出，在拉伸时具有 0.1 V 的体内输出。使用多种先进的成像技术，包括计算机断层扫描 (CT)、超声和光声来表征体内嵌入的 i-NG。 i-NGs 与邻近肌肉表面保持良好的粘附力，并在整个检查期间表现出稳定的电输出。通过病理分析和血液和血清检测，周围组织以及全身功能均未观察到毒性或不相容的迹象。 PDMS 包还能够有效地隔离生物环境中的 i-NG，并且 pA 级的杂散电流可以忽略不计。这一系列的体内和体外研究证实了在体内使用 i-NG 进行生物力学能量收集的生物学可行性。研究了基于 PVDF 的 NGs 在雌性 ICR 小鼠中的长期生物相容性和生物安全性。虽然没有观察到由包装的 NG 引起的毒性或不相容性迹象，但设备的完整性（包括 PVDF 功能和电极覆盖范围）得到了很好的保留。此外，在整个植入期间没有发现电力输出减少，确保了电力安全操作。这些系统研究为实际i-NG系统植入提供了基石。
Implantable nanogenerator (i-NG) has shown great promises for enabling self-powered implantable medical devices (IMDs). One essential requirement for practical i-NG applications is its long-term bio-compatibility and bio-safety. This paper presents a systematic study of polydimethylsiloxane (PDMS) and PDMS/Parylene-C packaged Polyvinylidene fluoride (PVDF) NGs implanted inside female ICR (Institute of Cancer Research) mice for up to six months. The PVDF NG had a stable in vitro output of 0.3 V when bended for 7200 cycles and an in vivo output of 0.1V under stretching. Multiple advanced imaging techniques, including computed tomography (CT), ultrasound, and photoacoustic were used to characterize the embedded i-NGs in vivo. The i-NGs kept excellent adhesion to the adjacent muscle surface, and exhibited stable electrical output during the entire examine period. No signs of toxicity or incompatibility were observed from the surrounding tissues, as well as from the whole body functions by pathological analyses and blood and serum test. The PDMS package was also able to effectively insulate the i-NG in biological environment with negligible stray currents at a pA scale. This series of in-vivo and in-vitro study confirmed the biological feasibility of using i-NG in vivo for biomechanical energy harvesting. The long-term bio-compatibility and bio-safety of PVDF-based NGs in female ICR mice were studied. While no signs of toxicity or incompatibility induced by the packaged NGs were observed, the device integrity including PVDF functionality and electrode coverage was well preserved. Moreover, no reduction in electrical outputs was found over the entire implantation period, ensuring an electrically safe operation. These systematic studies provide a cornerstone for practical i-NG system implantation.
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