The first 12 months of COVID-19: a timeline of immunological insights.

The first 12 months of COVID-19: a timeline of immunological insights.
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DOI:
10.1038/s41577-021-00522-1
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发表时间:
2021-04
期刊:
Nature reviews. Immunology
影响因子:
--
通讯作者:
Iwasaki A
Iwasaki A
中科院分区:
其他
文献类型:
--
作者:
Carvalho T;Krammer F;Iwasaki A

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自2019年12月中国武汉首次报告一批来源不明的肺炎病例以来,导致这种疾病的新型冠状病毒--严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)--已在全球蔓延,引发了二十一世纪世纪最致命的大流行。在过去的12个月里,无数实验室提供了大量令人眼花缭乱的信息,涵盖了从SARS-CoV-2的假定起源到众多候选疫苗的开发的所有内容。许多免疫学家迅速从他们现有的研究转向关注2019冠状病毒病(COVID-19),由于对一种病毒感染的这种前所未有的集中努力,已经通过预印本服务器和同行评审期刊产生和传播了大量工作。在这里,我们将带读者浏览大流行第一年期间的关键发现的时间轴,它展示了我们对SARS-CoV-2免疫反应的理解的非凡飞跃,并强调了我们知识的差距以及未来研究的领域。COVID-19大流行第一年的重大科学发现的时间轴展示了合作努力,使SARS-CoV-2免疫反应的关键方面以前所未有的速度得到报道。
Since the initial reports of a cluster of pneumonia cases of unidentified origin in Wuhan, China, in December 2019, the novel coronavirus that causes this disease — severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) — has spread throughout the world, igniting the twenty-first century’s deadliest pandemic. Over the past 12 months, a dizzying array of information has emerged from numerous laboratories, covering everything from the putative origin of SARS-CoV-2 to the development of numerous candidate vaccines. Many immunologists quickly pivoted from their existing research to focus on coronavirus disease 2019 (COVID-19) and, owing to this unprecedented convergence of efforts on one viral infection, a remarkable body of work has been produced and disseminated, through both preprint servers and peer-reviewed journals. Here, we take readers through the timeline of key discoveries during the first year of the pandemic, which showcases the extraordinary leaps in our understanding of the immune response to SARS-CoV-2 and highlights gaps in our knowledge as well as areas for future investigations. A timeline of the major scientific discoveries during the first year of the COVID-19 pandemic showcases the collaborative efforts that enabled the key aspects of the immune response to SARS-CoV-2 to be reported at unprecedented speed.
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