Hosts and Sources of Endemic Human Coronaviruses.
Hosts and Sources of Endemic Human Coronaviruses.
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DOI：
10.1016/bs.aivir.2018.01.001
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发表时间：
2018
影响因子：
--
通讯作者：
Drosten C
中科院分区：
文献类型：
--
作者：
Corman VM;Muth D;Niemeyer D;Drosten C
四种地方性人类冠状病毒HCoV-229 E、-NL 63、-OC 43和-HKU 1在成人和儿童的上呼吸道和下呼吸道感染中占相当大的份额。虽然它们的临床表现与许多其他普通感冒病原体相似，但它们的进化史和宿主关系可以为了解过去人类大流行病的自然史提供重要的见解。对于其中两种病毒，我们有强有力的证据表明起源于主要的牲畜物种，而所有四种病毒的原始关联可能存在于蝙蝠和啮齿动物中。HCoV-NL 63和-229E可能来源于蝙蝠宿主，正如许多其他冠状病毒所假设的那样，但HCoV-OC 43和-HKU 1似乎更可能来自啮齿动物相关病毒。HCoV-OC 43被认为是从家畜如牛或猪的祖先中出现的。牛冠状病毒被认为是一个可能的祖先，HCoV-OC 43可能是在世纪末历史记录的大流行背景下出现的。新的数据表明，HCoV-229 E实际上可能是从单峰骆驼传播的，类似于中东呼吸综合征（MERS）冠状病毒。这种情况提供了重要的生态相似之处，目前流行前的模式，宿主协会的中东呼吸综合征冠状病毒。
The four endemic human coronaviruses HCoV-229E, -NL63, -OC43, and -HKU1 contribute a considerable share of upper and lower respiratory tract infections in adults and children. While their clinical representation resembles that of many other agents of the common cold, their evolutionary histories, and host associations could provide important insights into the natural history of past human pandemics. For two of these viruses, we have strong evidence suggesting an origin in major livestock species while primordial associations for all four viruses may have existed with bats and rodents. HCoV-NL63 and -229E may originate from bat reservoirs as assumed for many other coronaviruses, but HCoV-OC43 and -HKU1 seem more likely to have speciated from rodent-associated viruses. HCoV-OC43 is thought to have emerged from ancestors in domestic animals such as cattle or swine. The bovine coronavirus has been suggested to be a possible ancestor, from which HCoV-OC43 may have emerged in the context of a pandemic recorded historically at the end of the 19th century. New data suggest that HCoV-229E may actually be transferred from dromedary camels similar to Middle East respiratory syndrome (MERS) coronavirus. This scenario provides important ecological parallels to the present prepandemic pattern of host associations of the MERS coronavirus.
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影响因子：
16.6
作者：
通讯作者：
--
DOI：
10.1093/cid/ciu812
发表时间：
2015-02-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Drosten C;Muth D;Corman VM;Hussain R;Al Masri M;HajOmar W;Landt O;Assiri A;Eckerle I;Al Shangiti A;Al-Tawfiq JA;Albarrak A;Zumla A;Rambaut A;Memish ZA
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影响因子：
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作者：
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通讯作者：
Saif, Linda J.
影响因子：
5.4
作者：
Corman, Victor Max;Baldwin, Heather J.;Drexler, Jan Felix
通讯作者：
Drexler, Jan Felix
影响因子：
120.7
作者：
Berkley, James A.;Munywoki, Patrick;Ngama, Mwanajuma;Kazungu, Sidi;Abwao, John;Bett, Anne;Lassauniere, Ria;Kresfelder, Tina;Cane, Patricia A.;Venter, Marietjie;Scott, J. Anthony G.;Nokes, D. James
通讯作者：
Nokes, D. James