In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca(2+) Fluxes.

In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca(2+) Fluxes.
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在正确的时间在正确的地方:IP3R介导的细胞器间钙(2+)流动对细胞代谢的调节

DOI:
10.3389/fcell.2021.629522
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发表时间:
2021
影响因子:
5.5
通讯作者:
Cárdenas C
Cárdenas C
中科院分区:
生物学2区
文献类型:
--
作者:
Ahumada-Castro U;Bustos G;Silva-Pavez E;Puebla-Huerta A;Lovy A;Cárdenas C

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在过去的几年中,代谢已被证明是由跨细胞器通信控制的。内质网和线粒体/溶酶体之间的关系是研究最多的;在这里,肌醇1,4,5-三磷酸(IP 3)受体(IP 3R)介导的钙(Ca 2+)释放起着核心作用。最近的证据表明,IP 3R亚型参与合成和降解途径。这篇小综述将总结这一领域目前的研究结果,强调Ca 2+通讯对细胞器功能以及catalysts和analysts的关键作用,特别是在癌症中。
In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca2+) release plays a central role. Recent evidence suggests that IP3R isoforms participate in synthesis and degradation pathways. This minireview will summarize the current findings in this area, emphasizing the critical role of Ca2+ communication on organelle function as well as catabolism and anabolism, particularly in cancer.
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