A revised and extended systematic review and meta-analysis of the relationship between childhood adversity and adult psychiatric disorder.
A revised and extended systematic review and meta-analysis of the relationship between childhood adversity and adult psychiatric disorder.
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对童年逆境与成人精神疾病之间关系的修订和扩展系统回顾和荟萃分析。
DOI：
10.1016/j.jpsychires.2022.10.015
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发表时间：
2022
影响因子：
4.8
通讯作者：
M. Clarke
中科院分区：
文献类型：
--
作者：
M. McKay;Leah Kilmartin;Alexandra Meagher;M. Cannon;C. Healy;M. Clarke
本研究旨在系统地回顾儿童期（≤ 17岁）经历的逆境与成年后精神障碍诊断之间的关联证据。检索电子数据库（Scopus、Medline（用于奥维德）、EMBASE和PsychINFO）中同行评议的纵向队列研究，研究儿童或青少年暴露于逆境，以及成人诊断的抑郁症、焦虑症、精神病性障碍、进食障碍、物质滥用障碍、疾病焦虑症、躯体形式障碍或人格障碍。共保留了39份手稿。结果显示，以下儿童期暴露与成人精神障碍之间存在显著相关性（1.24 ≤比值比≤ 2.09）：欺凌（受害者身份和频率）;情感虐待;忽视;身体虐待;失去父母;和一般虐待（未指明和/或多重逆境暴露）。作为一个被欺凌的肇事者有相反的结果，性虐待的结果在统计上并不显著。有一些证据表明，暴露于多种形式的虐待的人患精神障碍的几率为2.5倍（比值比= 2.59），这与剂量反应有关。性虐待的结果很可能是对这种逆境的预期评估的假象。总之，有强有力的证据表明童年逆境与后来的精神疾病之间存在关联，这支持了先前报道的荟萃分析。有证据表明，儿童和青少年时期是日后患精神疾病风险的重要时期，也是针对那些已知曾遭受逆境，特别是多重逆境的人采取干预策略的重要时期。
This study aimed to systematically review the evidence for an association between adversity experienced in childhood (≤ 17 years old), and the diagnosis of psychiatric disorder in adulthood. Electronic databases (Scopus, Medline (for Ovid), EMBASE, and PsychINFO) were searched for peer-reviewed, longitudinal cohort studies examining child or adolescent exposure to adversity, and adult-diagnosed depression, anxiety, psychotic disorder, eating disorders, substance abuse disorder, illness anxiety disorder, somatoform disorder, or personality disorder. A total of 39 manuscripts were retained. Results revealed a significant association between the following childhood exposures and adult mental disorder (1.24 ≤ Odds ratios ≤ 2.09): bullying (victimhood, and frequency); emotional abuse; neglect; physical abuse; parental loss; and general maltreatment (unspecified and/or multiple adversity exposure). There were opposing results for being a victimandperpetrator of bullying, and the result for sexual abuse was not statistically significant. There was some evidence of a dose-response relationship with those exposed to multiple forms of maltreatment having more two and a half times odds of developing a mental disorder (Odds ratio = 2.59). The result for sexual abuse is likely an artefact of the prospective assessment of this adversity. In summary, there was strong evidence of an association between childhood adversity and later mental illness, and this supports previously reported meta-analyses. The evidence suggests that childhood and adolescence is an important time for risk for later mental illness, and an important period in which to focus intervention strategies for those known to have been exposed to adversity, particularly multiple adversities.
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影响因子：
--
作者：
Jaffee, SR;Moffitt, TE;Martin, J
通讯作者：
Martin, J
影响因子：
25.8
作者：
Copeland, William E.;Wolke, Dieter;Angold, Adrian;Costello, E. Jane
通讯作者：
Costello, E. Jane
受虐待和被忽视儿童酗酒的后续调查：他们的风险是否增加？
DOI：
10.15288/jsa.1995.56.207
发表时间：
1995
期刊：
Journal of studies on alcohol
影响因子：
--
作者：
Widom,CS;Ireland,T;Glynn,PJ
通讯作者：
Glynn,PJ
影响因子：
2.4
作者：
Nikulina, Valentina;Widom, Cathy Spatz
通讯作者：
Widom, Cathy Spatz
影响因子：
6.9
作者：
Shanahan, L.;Copeland, W. E.;Costello, E. J.;Angold, A.
通讯作者：
Angold, A.