Free radical injury to skeletal muscles of young, adult, and old mice.
Free radical injury to skeletal muscles of young, adult, and old mice.
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自由基对年轻、成年和老年小鼠骨骼肌的损伤。
DOI：
10.1152/ajpcell.1990.258.3.c429
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Faulkner,JA
中科院分区：
文献类型：
--
作者：
Zerba,E;Komorowski,TE;Faulkner,JA
我们测试了以下假设：1）老年小鼠的肌肉比年轻和成年小鼠的肌肉更容易受伤，2）自由基损伤导致继发性或延迟性损伤。通过延长收缩原位损伤趾长伸肌。通过测量最大等长强直力（Po）（表示为对照值的百分比）和形态学损伤来评估损伤。用自由基清除剂聚乙二醇超氧化物歧化酶（PEG-SOD）处理小鼠。伤后3天，未治疗的老年小鼠肌肉的Po为44%，显著低于年轻和成年小鼠的Po为58%和61%。PEG-SOD治疗后第3天，各组动物的继发性损伤均减轻。对于年轻，成年和老年小鼠的治疗肌肉，PO值分别为88，80和70%。我们的结论是，老年小鼠的肌肉比年轻或成年小鼠的肌肉更容易受伤，自由基有助于继发性或延迟性损伤。
We tested the hypotheses that 1) muscles of old mice are more susceptible to injury than muscles of young and adult mice, and 2) secondary or delayed onset injury results from free radical damage. Extensor digitorum longus muscles were injured in situ by lengthening contractions. Injury was assessed by measurement of maximum isometric tetanic force (Po) expressed as a percentage of the control value and by morphological damage. Mice were treated with a free radical scavenger, polyethylene glycol-superoxide dismutase (PEG-SOD). Three days postinjury, the Po of 44% for muscles of nontreated old mice was significantly lower than the Po of 58 and 61% for those of young and adult mice. In each group, the secondary injury at 3 days was alleviated by treatment with PEG-SOD. For treated muscles of young, adult, and old mice, values for Po were 88, 80, and 70%, respectively. We conclude that muscles of old mice are more susceptible to injury than muscles of young or adult mice and that free radicals contribute to the secondary or delayed onset injury.
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力竭运动、耐力训练和骨骼肌酸水解酶活性。
DOI：
--
发表时间：
1979
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
V. Vihko;A. Salminen;J. Rantamäki
通讯作者：
J. Rantamäki
通过体外核糖体测定确定衰老过程中蛋白质合成的调节发生变化
影响因子：
3.9
作者：
G. W. Britton;F. Sherman
通讯作者：
F. Sherman
影响因子：
3.3
作者：
ARMSTRONG, RB;OGILVIE, RW;SCHWANE, JA
通讯作者：
SCHWANE, JA
影响因子：
20.1
作者：
KORTHUIS, RJ;GRANGER, DN;TAYLOR, AE
通讯作者：
TAYLOR, AE
影响因子：
5.5
作者：
BROOKS, SV;FAULKNER, JA
通讯作者：
FAULKNER, JA