DNA methylation dynamics in muscle development and disease.
DNA methylation dynamics in muscle development and disease.
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DOI：
10.3389/fnagi.2015.00019
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发表时间：
2015
影响因子：
4.8
通讯作者：
Suelves M
中科院分区：
文献类型：
--
作者：
Carrió E;Suelves M
DNA甲基化是哺乳动物发育所必需的表观遗传修饰，对细胞身份的建立和维持至关重要。传统上，DNA甲基化被认为是一种永久性的抑制性表观遗传标记。然而，全基因组方法的应用已经允许在不同基因组背景下分析DNA甲基化，揭示了比最初认为的更动态的调节，因为活跃的DNA甲基化和去甲基化发生在细胞分化和组织特化期间。卫星细胞是成年骨骼肌中的主要干细胞，负责出生后肌肉生长、肥大和肌肉再生。这篇综述概述了已发表的数据，DNA甲基化变化沿着骨骼肌程序，在生理和病理条件下，以更好地了解控制肌肉发生的表观遗传机制。
DNA methylation is an essential epigenetic modification for mammalian development and is crucial for the establishment and maintenance of cellular identity. Traditionally, DNA methylation has been considered as a permanent repressive epigenetic mark. However, the application of genome-wide approaches has allowed the analysis of DNA methylation in different genomic contexts revealing a more dynamic regulation than originally thought, since active DNA methylation and demethylation occur during cellular differentiation and tissue specification. Satellite cells are the primary stem cells in adult skeletal muscle and are responsible for postnatal muscle growth, hypertrophy, and muscle regeneration. This review outlines the published data regarding DNA methylation changes along the skeletal muscle program, in both physiological and pathological conditions, to better understand the epigenetic mechanisms that control myogenesis.
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影响因子：
23.9
作者：
Dawlaty, Meelad M.;Ganz, Kibibi;Powell, Benjamin E.;Hu, Yueh-Chiang;Markoulaki, Styliani;Cheng, Albert W.;Gao, Qing;Kim, Jongpil;Choi, Sang-Woon;Page, David C.;Jaenisch, Rudolf
通讯作者：
Jaenisch, Rudolf
影响因子：
14.9
作者：
Calvanese V;Fernández AF;Urdinguio RG;Suárez-Alvarez B;Mangas C;Pérez-García V;Bueno C;Montes R;Ramos-Mejía V;Martínez-Camblor P;Ferrero C;Assenov Y;Bock C;Menendez P;Carrera AC;Lopez-Larrea C;Fraga MF
通讯作者：
Fraga MF
影响因子：
29
作者：
Barres, Romain;Yan, Jie;Zierath, Juleen R.
通讯作者：
Zierath, Juleen R.
影响因子：
64.5
作者：
CHIU, CP;BLAU, HM
通讯作者：
BLAU, HM
影响因子：
11.4
作者：
BOYES, J;BIRD, A
通讯作者：
BIRD, A