Insecticide-treated eave nets and window screens for malaria control in Chalinze district, Tanzania: a study protocol for a household randomised control trial.
Insecticide-treated eave nets and window screens for malaria control in Chalinze district, Tanzania: a study protocol for a household randomised control trial.
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长效杀虫蚊帐有助于减少包括坦桑尼亚在内的撒哈拉以南非洲地区的疟疾。然而，它们依赖于日常用户行为和高覆盖率，这很难维护。此外，疟疾媒介蚊子对杀虫剂的抗药性也降低了控制工具的效力。为了克服这些问题，我们建议评估一种新的房屋改造工具，杀虫剂处理的屋檐网(ITEN)与杀虫剂处理的窗纱(ITW)相结合，其中包含具有双活性成分(双重AI)的，用于控制疟疾。在查林泽区，墙壁完好、屋檐敞开、窗户上没有纱网或网的家庭将有资格获得资格并经书面知情同意后被招募。这些家庭将被随机分配到两个手臂：一个安装了ITEN和ITWS，另一个没有安装。利用定量聚合酶链式反应检测疟疾寄生虫将在作为主要结果的长雨(2022年6月/7月)之后不久和作为次要结果的短雨(2022年1月/2月)之后不久进行。其他次要结果包括临床疟疾病例、疟疾病媒密度以及短雨和长雨后的滋扰。此外，还将在拥有ITEN和ITWS的家庭中进行调查，以估计安装期间的干预成本、安装后一个月的不良影响以及安装后六个月和十二个月的存在、结构完整性和用户接受度。生物效果和化学含量将在安装后12个月进行评估。肯尼亚已经表明，ITEN和ITWS可以降低室内蚊子密度。然而，目前尚不清楚室内蚊子密度的减少是否会转化为疟疾病例的减少。这项研究的数据将衡量在不需要每天坚持的蚊子杀虫剂抗性地区，在家庭一级额外干预疟疾控制的潜在公共卫生价值。这项研究在ClinicalTrials.gov上注册。网上版载有补充材料，可在10.1186/s13063-022-06408-4查阅。
Long-lasting insecticidal nets (LLINs) have contributed to the reduction of malaria in sub-Saharan Africa, including Tanzania. However, they rely on daily user behaviour and high coverage which is difficult to maintain. Also, insecticide resistance among malaria vector mosquitoes is contributing to reduced efficacy of control tools. To overcome these problems, we propose to evaluate a new tool for house modification, the insecticide-treated eave nets (ITENs) in combination with insecticide-treated window screens (ITWS) incorporated with dual active ingredient (dual AI) for the control of malaria. Four hundred and fifty (450) households with intact walls, open eaves without screens or nets on the windows in Chalinze district will be eligible and recruited upon written informed consent. The households will be randomly allocated into two arms: one with ITENs and ITWS installed and the other without. Malaria parasite detection using a quantitative polymerase chain reaction (qPCR) will be conducted shortly after the long rain (June/July, 2022) as the primary outcome and shortly after the short rain (January/February, 2022) as the secondary outcome. Other secondary outcomes include clinical malaria cases, and density of malaria vectors and nuisance after the short rain and long rain. In addition, surveys will be conducted in households with ITENs and ITWS to estimate the intervention’s cost during installation, adverse effects one month after installation, and presence, fabric integrity and user acceptance six and twelve months after installation. Bioefficacy and chemical content will be evaluated twelve months after installation. ITENs and ITWS have been shown in Kenya to reduce indoor mosquito density. However, it is not known if indoor mosquito density reduction translates into reduction of malaria cases. Data from the study will measure the potential public health value of an additional intervention for malaria control at the household level in areas of mosquito insecticide resistance that does not require daily adherence. The study is registered on ClinicalTrials.gov. The online version contains supplementary material available at 10.1186/s13063-022-06408-4.
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影响因子：
3.7
作者：
Gnanguenon V;Azondekon R;Oke-Agbo F;Beach R;Akogbeto M
通讯作者：
Akogbeto M
DOI：
10.4269/ajtmh.2003.68.121
发表时间：
2003-04-01
影响因子：
3.3
作者：
Hawley, WA;Phillips-Howard, PA;Hightower, AW
通讯作者：
Hightower, AW
DOI：
10.4269/ajtmh.1998.59.595
发表时间：
1998-10-01
影响因子：
3.3
作者：
Mboera, LEG;Kihonda, J;Knols, BGJ
通讯作者：
Knols, BGJ
影响因子：
3
作者：
Mboma, Zawadi M.;Overgaard, Hans J.;Lorenz, Lena M.
通讯作者：
Lorenz, Lena M.
影响因子：
3
作者：
Schindler, Tobias;Robaina, Tamy;Daubenberger, Claudia
通讯作者：
Daubenberger, Claudia