MRSI of the medial temporal lobe at 7 T in explosive blast mild traumatic brain injury.
MRSI of the medial temporal lobe at 7 T in explosive blast mild traumatic brain injury.
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DOI：
10.1002/mrm.24814
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发表时间：
2014-04
影响因子：
3.3
通讯作者：
Pan, Jullie W.
中科院分区：
文献类型：
--
作者：
Hetherington, Hoby P.;Hamid, Hamada;Kulas, Joseph;Ling, Geoffrey;Bandak, Faris;de Lanerolle, Nihal C.;Pan, Jullie W.
Up to 19% of veterans returning from the wars in Iraq and Afghanistan have a history of mild traumatic brain injury (mTBI) with 70% associated with blast exposure. Tragically, 20–50% of this group reports persistent symptoms, including memory loss. Unfortunately, routine clinical imaging is typically normal, making diagnosis and clinical management difficult. The goal of this work was to develop methods to acquire hippocampal MRSI at 7T and evaluate their sensitivity to detect injury in veterans with mTBI. At 7T, hippocampal MRSI measurements are limited by: 1) poor B0 homogeneity; 2) insufficient B1+ strength and homogeneity; and 3) chemical shift dispersion artifacts. To overcome these limitations we: 1) used 3rd degree B0 shimming; 2) an inductively decoupled transceiver array with RF shimming and 3) a volume localized single slice sequence using RF shimming based outer volume suppression. In 20 controls and 25 veterans with mTBI due to blast exposure with memory impairment, hippocampal NAA/Cho (P<0.001) and NAA/Cr (P<0.001) were decreased in comparison to control subjects. With the appropriate methods robust spectroscopic imaging of the hippocampus can be carried out at 7T. MRSI at 7T can detect hippocampal injury in veterans with mild traumatic brain injury.
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影响因子：
4.4
作者：
Babikian, Talin;Freier, M. Catherin;Holshouser, Barbara A.
通讯作者：
Holshouser, Barbara A.
影响因子：
4.4
作者：
Miyasaka, Naoyuki;Takahashi, Kan;Hetherington, Hoby P.
通讯作者：
Hetherington, Hoby P.
影响因子：
1.9
作者：
Flaro, Lloyd;Green, Paul;Robertson, Ellen
通讯作者：
Robertson, Ellen
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
4.2
作者：
Lu, Jia;Ng, Kian Chye;Ling, Eng-Ang
通讯作者：
Ling, Eng-Ang