Aldosterone antagonists in monotherapy are protective against streptozotocin-induced diabetic nephropathy in rats.
Aldosterone antagonists in monotherapy are protective against streptozotocin-induced diabetic nephropathy in rats.
复制标题
DOI：
10.1371/journal.pone.0039938
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Fekete A
中科院分区：
文献类型：
--
作者：
Banki NF;Ver A;Wagner LJ;Vannay A;Degrell P;Prokai A;Gellai R;Lenart L;Szakal DN;Kenesei E;Rosta K;Reusz G;Szabo AJ;Tulassay T;Baylis C;Fekete A
Angiotensin converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) are the standard clinical therapy of diabetic nephropathy (DN), while aldosterone antagonists are only used as adjuncts. Previously in experimental DN we showed that Na/K ATPase (NKA) is mislocated and angiotensin II leads to superimposed renal progression. Here we investigated the monotherapeutic effect of aldosterone blockers on the progression of DN and renal NKA alteration in comparison to ACEi and ARBs. Streptozotocin-diabetic rats developing DN were treated with aldosterone antagonists; ACEi and ARB. Renal function, morphology, protein level and tubular localization of NKA were analyzed. To evaluate the effect of high glucose per se; HK-2 proximal tubular cells were cultured in normal or high concentration of glucose and treated with the same agents. Aldosterone antagonists were the most effective in ameliorating functional and structural kidney damage and they normalized diabetes induced bradycardia and weight loss. Aldosterone blockers also prevented hyperglycemia and diabetes induced increase in NKA protein level and enzyme mislocation. A monotherapy with aldosterone antagonists might be as, or more effective than ACEi or ARBs in the prevention of STZ-induced DN. Furthermore the alteration of the NKA could represent a novel pathophysiological feature of DN and might serve as an additional target of aldosterone blockers.
登录
查看更多内容
影响因子：
4.8
作者：
BELL, RC;KHURANA, M;FINEGOOD, DT
通讯作者：
FINEGOOD, DT
影响因子：
3
作者：
Goyal, Bhoomika R.;Solanki, Nilay;Mehta, Anita A.
通讯作者：
Mehta, Anita A.
影响因子：
3.7
作者：
Galuska, Dana;Pirkmajer, Sergej;Chibalin, Alexander V.
通讯作者：
Chibalin, Alexander V.
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
3.4
作者：
Al-Achi, A;Greenwood, R
通讯作者：
Greenwood, R