Metabolomics Monitoring of Treatment Response to Brain Tumor Immunotherapy.
Metabolomics Monitoring of Treatment Response to Brain Tumor Immunotherapy.
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DOI：
10.3389/fonc.2021.691246
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发表时间：
2021
影响因子：
4.7
通讯作者：
Rahman M
中科院分区：
文献类型：
--
作者：
Dastmalchi F;Deleyrolle LP;Karachi A;Mitchell DA;Rahman M
免疫疗法已经彻底改变了许多实体组织恶性肿瘤的护理，并且正在研究治疗恶性脑肿瘤的疗效。确定一种非侵入性监测技术，如代谢组学监测，以预测患者对免疫治疗的反应，有可能简化治疗决策，并确保根据早期患者反应量身定制治疗。外周免疫反应的代谢组学分析是可行的，因为免疫细胞在激活时经历了巨大的代谢变化。目前正在调查这种方法的效用。在这篇综述中，我们讨论了免疫反应激活过程中诱导的代谢变化，以及代谢谱在恶性脑肿瘤免疫治疗中监测免疫反应的作用。这篇综述为代谢组学监测如何在肿瘤免疫治疗领域产生重要影响提供了独到的见解。
Immunotherapy has revolutionized care for many solid tissue malignancies, and is being investigated for efficacy in the treatment of malignant brain tumors. Identifying a non-invasive monitoring technique such as metabolomics monitoring to predict patient response to immunotherapy has the potential to simplify treatment decision-making and to ensure therapy is tailored based on early patient response. Metabolomic analysis of peripheral immune response is feasible due to large metabolic shifts that immune cells undergo when activated. The utility of this approach is under investigation. In this review, we discuss the metabolic changes induced during activation of an immune response, and the role of metabolic profiling to monitor immune responses in the context of immunotherapy for malignant brain tumors. This review provides original insights into how metabolomics monitoring could have an important impact in the field of tumor immunotherapy if achievable.
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影响因子：
10.5
作者：
Amankulor NM;Kim Y;Arora S;Kargl J;Szulzewsky F;Hanke M;Margineantu DH;Rao A;Bolouri H;Delrow J;Hockenbery D;Houghton AM;Holland EC
通讯作者：
Holland EC
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
--
作者：
Koido S;Homma S;Takahara A;Namiki Y;Komita H;Nagasaki E;Ito M;Nagatsuma K;Uchiyama K;Satoh K;Ohkusa T;Gong J;Tajiri H
通讯作者：
Tajiri H
DOI：
10.1016/0304-4165(76)90005-2
发表时间：
1976-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
CULVENOR, JG;WEIDEMANN, MJ
通讯作者：
WEIDEMANN, MJ
影响因子：
10.9
作者：
Dastmalchi, Farhad;Karachi, Aida;Rahman, Maryam
通讯作者：
Rahman, Maryam