Ionotropic and metabotropic proton-sensing receptors involved in airway inflammation in allergic asthma.
Ionotropic and metabotropic proton-sensing receptors involved in airway inflammation in allergic asthma.
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DOI：
10.1155/2014/712962
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发表时间：
2014
影响因子：
4.6
通讯作者：
Okajima F
中科院分区：
文献类型：
--
作者：
Aoki H;Mogi C;Okajima F
酸性微环境已显示引起多种气道反应，包括咳嗽、支气管收缩、气道高反应性（AHR）、肺中炎性细胞浸润和刺激粘液过度产生。除了瞬时受体电位香草素-1（TRPV 1）和酸敏感离子通道（ASIC）通过感觉神经元参与严重酸性pH（小于6.0）诱导的咳嗽和支气管收缩外，气道中细胞外酸性pH诱导作用的分子机制尚未完全了解。最近的研究表明，卵巢癌G蛋白偶联受体1（OGR 1）家族G蛋白偶联受体，其感知pH值超过6.0，在结构细胞，如气道平滑肌细胞和上皮细胞，以及炎症和免疫细胞，如嗜酸性粒细胞和树突状细胞中表达。它们在与炎症性疾病（包括过敏性哮喘）的病理生理学相关的各种气道反应中发挥作用。本文就离子型TRPV 1、ASICs和代谢型OGR 1家族G蛋白偶联受体在哮喘和呼吸系统疾病气道炎症和AHR中的作用进行综述。
An acidic microenvironment has been shown to evoke a variety of airway responses, including cough, bronchoconstriction, airway hyperresponsiveness (AHR), infiltration of inflammatory cells in the lung, and stimulation of mucus hyperproduction. Except for the participation of transient receptor potential vanilloid-1 (TRPV1) and acid-sensing ion channels (ASICs) in severe acidic pH (of less than 6.0)-induced cough and bronchoconstriction through sensory neurons, the molecular mechanisms underlying extracellular acidic pH-induced actions in the airways have not been fully understood. Recent studies have revealed that ovarian cancer G protein-coupled receptor 1 (OGR1)-family G protein-coupled receptors, which sense pH of more than 6.0, are expressed in structural cells, such as airway smooth muscle cells and epithelial cells, and in inflammatory and immune cells, such as eosinophils and dendritic cells. They function in a variety of airway responses related to the pathophysiology of inflammatory diseases, including allergic asthma. In the present review, we discuss the roles of ionotropic TRPV1 and ASICs and metabotropic OGR1-family G protein-coupled receptors in the airway inflammation and AHR in asthma and respiratory diseases.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
10.1073/pnas.0407780102
发表时间：
2005-04-05
影响因子：
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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