Modular architecture of metabolic brain network and its effects on the spread of perturbation impact
Modular architecture of metabolic brain network and its effects on the spread of perturbation impact
复制标题
代谢脑网络的模块化结构及其对扰动影响传播的影响
DOI：
10.1016/j.neuroimage.2018.11.003
复制
发表时间：
2019-02
期刊：
影响因子：
5.7
通讯作者：
Shan Baoci
中科院分区：
文献类型：
--
作者：
Zhang Tianhao;Huang Qi;Jiao Chunxiang;Liu Hua;Nie Binbin;Liang Shengxiang;Li Panlong;Sun Xi;Feng Ting;Xu Lin;Shan Baoci
基于18F-脱氧葡萄糖（FDG）正电子发射断层扫描（PET）图像功能相关模式的脑代谢网络已广泛应用于基础和临床神经科学。探索代谢脑网络的特性可以为脑的生理和病理过程提供有价值的见解。基于网络理论，模块化结构具有限制局部扰动影响传播的能力，因此模块化网络对外部损伤具有更强的鲁棒性。方法77只大鼠进行18F-FDG PET脑显像。然后，代谢脑网络构建跨学科的方式测量区域间的代谢相关性。然后，通过贪婪算法检测网络的模块化结构。此外，我们扰乱了代谢脑网络诱导局灶性光血栓缺血在双侧运动皮层，然后测量葡萄糖代谢的变化，每个大脑区域使用FDG-PET.ResultsA显着的模块化架构被发现在代谢脑网络。该网络可分为四个模块，大致对应于执行、学习/记忆、视觉/听觉和感觉运动处理功能域。在诱导双侧运动皮层局灶性缺血后，大部分显著改变的脑区（17个中的13个）属于感觉运动moduls.ConclusionOur结果揭示了代谢脑网络中固有的模块化结构，并给出了代谢脑网络的模块化可以限制局部扰动影响的传播的实验证据。
Metabolic brain network, which is based on functional correlation patterns of18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) images, has been widely applied in both basic and clinical neuroscience. Exploring the properties of the metabolic brain network can provide valuable insight to the physiologic and pathologic processes of the brain. Based on the network theory, modular architecture has the ability to limit the spread of local perturbation impact and therefore modular networks are more robust against external damage. However, whether the metabolic brain network has modular architecture remains unknown.Methods77 rats performed18F-FDG PET brain imaging. The metabolic brain network was then constructed by measuring interregional metabolic correlation in inter-subject manner. Afterwards, modular architecture of the network was detected by a greedy algorithm. Further, we perturbed the metabolic brain network by inducing focal photothrombotic ischemia in the bilateral motor cortex and then measured the glucose metabolic change of each brain region using FDG-PET.ResultsA significant modular architecture was found in the metabolic brain network. The network could be divided into four modules which corresponding approximately to executive, learning/memory, visual/auditory and sensorimotor processing functional domains. After inducing the focal ischemia on the bilateral motor cortex, most of the significantly changed brain regions (13 of 17) belong to the sensorimotor module.ConclusionOur results revealed an inherent modular architecture in the metabolic brain network and gave an experimental evidence that the modularity of the metabolism brain network could limit the spread of local perturbation impact.
登录
查看更多内容
影响因子：
15.9
作者：
Mergenthaler P;Lindauer U;Dienel GA;Meisel A
通讯作者：
Meisel A
影响因子：
4.8
作者：
Yakushev, Igor;Drzezga, Alexander;Habeck, Christian
通讯作者：
Habeck, Christian
影响因子：
4.8
作者：
Nie, Binbin;Chen, Kewei;Zhao, Shujun;Liu, Junhua;Gu, Xiaochun;Yao, Qunli;Hui, Jiaojie;Zhang, Zhijun;Teng, Gaojun;Zhao, Chunjie;Shan, Baoci
通讯作者：
Shan, Baoci
影响因子：
19.9
作者：
Sokolov AA;Miall RC;Ivry RB
通讯作者：
Ivry RB
DOI：
10.1098/rspb.2014.2568
发表时间：
2015-03-07
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Tosh CR;McNally L
通讯作者：
McNally L