The mediating impact of PTSD symptoms on cortisol awakening response in the context of intimate partner violence.
The mediating impact of PTSD symptoms on cortisol awakening response in the context of intimate partner violence.
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DOI：
10.1016/j.biopsycho.2020.107873
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发表时间：
2020-04
影响因子：
2.6
通讯作者：
Delahanty DL
中科院分区：
文献类型：
--
作者：
Garcia MA;Junglen A;Ceroni T;Johnson D;Ciesla J;Delahanty DL
多层次模型研究了 158 名患有亲密伴侣暴力相关 PTSD 的女性参与者样本中皮质醇觉醒反应 (CAR) 与不同 PTSD 症状群之间的关联。结果显示，过去一周和过去一个月的觉醒分别 ([β = -0.124, z = -2.33, p = .028;β = -.147, z = -2.19, p = .028]) 显着缓和了皮质醇水平的轨迹和情绪麻木症状的严重程度 (过去一周 [β = -0.122, z = -2.07, p = .076])被发现有显着性趋势。在每种情况下，与症状严重程度较低的患者相比，症状严重程度较高的患者的 CAR 斜率更平坦。与评估全球 PTSD 的研究相比，评估与皮质醇相关的 PTSD 症状群可能会更好地为未来的干预措施提供信息。我们的研究结果表明，表现出较高水平唤醒的 PTSD 患者亚型可能更有可能经历 HPA 轴功能的改变。
Multi-level modeling examined the association between cortisol awakening responses (CAR) and different PTSD symptom clusters in a sample of 158 female participants presenting with intimate partner violence-related PTSD. Results revealed that arousal over the past week and month, respectively ([β = −0.124, z = −2.33, p = .028; β = −.147, z = −2.19, p = .028]) significantly moderated the trajectory of cortisol levels, and emotional numbing symptom severity (over the past week [β = −0.122, z = −2.07, p = .076]) was found to be trending toward significance. In each case higher symptom severity was associated with flatter CAR slopes compared to those with lower symptom severity. Assessing PTSD symptom clusters in relation to cortisol may better inform future interventions compared to studies that assess PTSD globally. Our findings suggest a subtype of PTSD patients displaying higher levels of arousal may be more likely to experience alterations in HPA axis functioning.
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