Functional connectivity of the human amygdala using resting state fMRI.
Functional connectivity of the human amygdala using resting state fMRI.
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DOI：
10.1016/j.neuroimage.2008.11.030
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发表时间：
2009-04-01
期刊：
影响因子：
5.7
通讯作者：
Milham MP
中科院分区：
文献类型：
--
作者：
Roy AK;Shehzad Z;Margulies DS;Kelly AM;Uddin LQ;Gotimer K;Biswal BB;Castellanos FX;Milham MP
杏仁核由结构和功能不同的核团组成，这些核团通过与其他皮质下和皮质结构的相互作用来促进情绪的处理。虽然这些回路已经在动物身上进行了广泛的研究，但人类对杏仁核网络的神经成像研究通常将杏仁核视为单一结构，这可能掩盖了杏仁核各个亚区的贡献。本研究使用静息状态功能磁共振成像(FMRI)来测试是否可以像动物研究中观察到的那样，在杏仁核的三个亚区中检测到不同的功能连接模式：基底外侧、中央内侧和浅层。在65名健康成年人的样本中，体素回归分析显示，与之前的动物和人类研究一致，腹侧和背侧网络与整个杏仁核相关，呈阳性预测和阴性预测。对杏仁核各个分区的研究发现，杏仁核和整个大脑的连接模式明显不同。基底外侧区的自发活动预测了颞叶和额叶的活动，而中央内侧核的活动则预测了主要在纹状体的活动。浅层脑区的活动正预示着整个边缘叶的活动。这些发现表明，静息状态的功能磁共振成像可以用来研究人类杏仁核网络，其细节程度比之前估计的更高，从而允许进一步发展翻译模型。
The amygdala is composed of structurally and functionally distinct nuclei that contribute to the processing of emotion through interactions with other subcortical and cortical structures. While these circuits have been studied extensively in animals, human neuroimaging investigations of amygdala-based networks have typically considered the amygdala as a single structure, which likely masks contributions of individual amygdala subdivisions. The present study uses resting state functional magnetic resonance imaging (fMRI) to test whether distinct functional connectivity patterns, like those observed in animal studies, can be detected across three amygdala subdivisions: laterobasal, centromedial, and superficial. In a sample of 65 healthy adults, voxelwise regression analyses demonstrated positively-predicted ventral and negatively-predicted dorsal networks associated with the total amygdala, consistent with previous animal and human studies. Investigation of individual amygdala subdivisions revealed distinct differences in connectivity patterns within the amygdala and throughout the brain. Spontaneous activity in the laterobasal subdivision predicted activity in temporal and frontal regions, while activity in the centromedial nuclei predicted activity primarily in striatum. Activity in the superficial subdivision positively predicted activity throughout the limbic lobe. These findings suggest that resting state fMRI can be used to investigate human amygdala networks at a greater level of detail than previously appreciated, allowing for the further advancement of translational models.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
10.6
作者：
Davis, Michael;Ressler, Kerry;Richardson, Rick
通讯作者：
Richardson, Rick
影响因子：
3.1
作者：
Akirav I;Maroun M
通讯作者：
Maroun M
影响因子：
2.6
作者：
Fransson, Peter
通讯作者：
Fransson, Peter