Treating depression and depression-like behavior with physical activity: an immune perspective.
Treating depression and depression-like behavior with physical activity: an immune perspective.
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DOI：
10.3389/fpsyt.2013.00003
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发表时间：
2013
影响因子：
4.7
通讯作者：
Baune BT
中科院分区：
文献类型：
--
作者：
Eyre HA;Papps E;Baune BT
重性抑郁症的负担日益加重，这使得对病因学的深入了解和其他治疗方法的开发变得非常重要。生物学因素可能是体力活动（PA）治疗的有用生物标志物，PA的神经生物学效应可能预示着未来治疗的新发展。本文提供了一个全面的和最新的审查研究PA对抑郁症和抑郁样行为的大脑的神经免疫调节作用。从神经免疫的角度来看，有证据表明PA确实增强了神经免疫系统的有益作用，减少了有害作用。PA似乎增加了以下因子：白细胞介素（IL）-10，IL-6（急性），巨噬细胞迁移抑制因子，中枢神经系统特异性自身反应性CD 4 + T细胞，M2小胶质细胞，静止星形胶质细胞，CX 3CL 1和胰岛素样生长因子-1。另一方面，PA似乎减少有害的神经免疫因子，如：Th 1/Th 2平衡，促炎细胞因子，C-反应蛋白，M1小胶质细胞和反应性星形胶质细胞。其他机制的影响尚不清楚，如：CD 4 + CD 25 + T调节细胞（T细胞）、CD 200、趋化因子、miRNA、M2型血源性巨噬细胞和肿瘤坏死因子（TNF）-α [通过受体2（R2）]。PA的有益作用可能发生在中枢和外周（例如，内脏脂肪减少）。PA对抑郁症及抑郁样行为的神经免疫作用是一个迅速发展的重要研究领域。
The increasing burden of major depressive disorder makes the search for an extended understanding of etiology, and for the development of additional treatments highly significant. Biological factors may be useful biomarkers for treatment with physical activity (PA), and neurobiological effects of PA may herald new therapeutic development in the future. This paper provides a thorough and up-to-date review of studies examining the neuroimmunomodulatory effects of PA on the brain in depression and depression-like behaviors. From a neuroimmune perspective, evidence suggests PA does enhance the beneficial and reduce the detrimental effects of the neuroimmune system. PA appears to increase the following factors: interleukin (IL)-10, IL-6 (acutely), macrophage migration inhibitory factor, central nervous system-specific autoreactive CD4+ T cells, M2 microglia, quiescent astrocytes, CX3CL1, and insulin-like growth factor-1. On the other hand, PA appears to reduce detrimental neuroimmune factors such as: Th1/Th2 balance, pro-inflammatory cytokines, C-reactive protein, M1 microglia, and reactive astrocytes. The effect of other mechanisms is unknown, such as: CD4+CD25+ T regulatory cells (T regs), CD200, chemokines, miRNA, M2-type blood-derived macrophages, and tumor necrosis factor (TNF)-α [via receptor 2 (R2)]. The beneficial effects of PA are likely to occur centrally and peripherally (e.g., in visceral fat reduction). The investigation of the neuroimmune effects of PA on depression and depression-like behavior is a rapidly developing and important field.
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影响因子：
4.2
作者：
Bachstetter, Adam D.;Morganti, Josh M.;Jernberg, Jennifer;Schlunk, Andrea;Mitchell, Staten H.;Brewster, Kaelin W.;Hudson, Charles E.;Cole, Michael J.;Harrison, Jeffrey K.;Bickford, Paula C.;Gemma, Carmelina
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影响因子：
24
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通讯作者：
Hinderliter, Alan L.
影响因子：
6.2
作者：
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通讯作者：
Schwarz, Jaclyn M.
影响因子：
9.3
作者：
Baune, Bernhard T.;Konrad, Carsten;Dannlowski, Udo
通讯作者：
Dannlowski, Udo
影响因子：
3.3
作者：
Babyak, M;Blumenthal, JA;Krishnan, KR
通讯作者：
Krishnan, KR