Disruption of a Single Pten Allele Augments the Chemotactic Response of B Lymphocytes to Stromal Cell-Derived Factor-11
Disruption of a Single Pten Allele Augments the Chemotactic Response of B Lymphocytes to Stromal Cell-Derived Factor-11
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单个 Pten 等位基因的破坏增强 B 淋巴细胞对基质细胞衍生因子 11 的趋化反应
作者：
J. Fox;K. Ung;Sonia G. Tanlimco;F. Jirik
肿瘤抑制因子Pten已成为磷脂酰肌醇-3-激酶依赖性细胞内信号通路的关键负调节因子，该信号通路负责细胞粘附、增殖和凋亡等现象。在此，我们提出的证据表明，Pten调节B淋巴细胞中的趋化因子依赖性事件。从Pten+/−小鼠分离的原代B细胞表现出对基质细胞衍生因子-1诱导的趋化性的反应性增加。这伴随着Ser 473上蛋白激酶B磷酸化水平的升高。我们的研究结果表明，不仅Pten可能是一个重要的调节基质细胞衍生因子-1-定向趋化性，而且Pten杂合性与细胞敏感性增加，这种趋化因子，可能通过失调的事件躺在下游的磷脂酰肌醇-3-激酶。这些观察结果表明了一种机制，通过该机制，单个Pten等位基因的丢失可能在多步骤肿瘤进展期间赋予细胞选择性优势。
The tumor suppressor, Pten, has emerged as a critical negative regulator of phosphatidylinositol-3-kinase-dependent intracellular signaling pathways responsible for phenomena such as cellular adhesion, proliferation, and apoptosis. Herein, we present evidence that Pten regulates chemokine-dependent events in B lymphocytes. Primary B cells isolated from Pten+/− mice demonstrated increased responsiveness to stromal cell-derived factor-1-induced chemotaxis. This was accompanied by an elevated level of protein kinase B phosphorylation on Ser473. Our results suggest not only that Pten may be an important regulator of stromal cell-derived factor-1-directed chemotaxis, but also that Pten heterozygosity is associated with increased cellular sensitivity to this chemokine, likely via dysregulation of events lying downstream of phosphatidylinositol-3-kinase. These observations suggest a mechanism by which loss of a single Pten allele may confer a selective advantage on cells during multistep tumor progression.
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影响因子：
56.9
作者：
Di Cristofano, A;Kotsi, P;Pandolfi, PP
通讯作者：
Pandolfi, PP
DOI：
10.1073/pnas.96.4.1563
发表时间：
1999-02-16
影响因子：
11.1
作者：
Podsypanina, K;Ellenson, LH;Parsons, R
通讯作者：
Parsons, R
影响因子：
16
作者：
Lee, MJ;Thangada, S;Hla, T
通讯作者：
Hla, T
膜 Ig 交联调节 B 淋巴细胞中的磷脂酰肌醇 3-激酶。
DOI：
--
发表时间：
1992
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gold,MR;Chan,VW;Turck,CW;DeFranco,AL
通讯作者：
DeFranco,AL
影响因子：
56.9
作者：
Servant, G;Weiner, OD;Bourne, HR
通讯作者：
Bourne, HR