Synergic control of action in levodopa-naïve Parkinson's disease patients: II. Multi-muscle synergies stabilizing vertical posture.
Synergic control of action in levodopa-naïve Parkinson's disease patients: II. Multi-muscle synergies stabilizing vertical posture.
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DOI：
10.1007/s00221-020-05947-z
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发表时间：
2020-12
影响因子：
2
通讯作者：
Latash ML
中科院分区：
文献类型：
--
作者：
Freitas SMSF;de Freitas PB;Falaki A;Corson T;Lewis MM;Huang X;Latash ML
姿势不稳定是帕金森病（PD）的主要致残特征。我们在未接受过左旋多巴治疗的PD患者和年龄匹配的对照受试者中，将腿部和躯干肌肉的组织量化为协同作用，以稳定压力中心（COP）坐标。主要的假设是，在协同控制的姿势的变化是目前早期的PD过程中，甚至在左旋多巴曝光。11名左旋多巴初治的PD患者和11名健康对照者在站在测力板上时进行全身周期性自愿摇摆任务和自我启动的负荷释放任务。分析了身体右侧13块肌肉的表面肌电图活动，以确定具有平行缩放激活水平（M模式）的肌肉群。在25/100卡比多巴/左旋多巴的第一剂量之前（“停药”）和之后约60分钟（“用药”）收集数据。对于负荷释放任务，量化了稳定COP的协同作用。左旋多巴初治PD患者在“停药”时未显示COP稳定协同作用，而对照组显示姿势稳定多M模式协同作用。“药物中”，PD患者显示协同指数显著增加。药物对M模式组成、预期姿势调整、运动等效性指数或COP变异性指数无显著影响。结果表明，左旋多巴初治的PD患者已经显示出受损的姿势稳定多肌肉协同作用，可用作PD中新兴姿势障碍的有前途的行为生物标志物。此外，左旋多巴在这些左旋多巴初治患者中的协同作用指标与之前对慢性抗帕金森病药物患者的研究不同，表明不同的神经回路参与。
Postural instability is a major disabling feature in Parkinson’s disease (PD). We quantified the organization of leg and trunk muscles into synergies stabilizing the center of pressure (COP) coordinate within the uncontrolled manifold hypothesis in levodopa-naïve patients with PD and age-matched control subjects. The main hypothesis was that changes in the synergic control of posture are present early in the PD process even before levodopa exposure. Eleven levodopa-naïve patients with PD and 11 healthy controls performed whole-body cyclical voluntary sway tasks and a self-initiated load-release task during standing on a force plate. Surface electromyographic activity in 13 muscles on the right side of the body was analyzed to identify muscle groups with parallel scaling of activation levels (M-modes). Data were collected both before (“off-drug”) and approximately 60 min after the first dose of 25/100 carbidopa/levodopa (“on-drug”). COP-stabilizing synergies were quantified for the load-release task. Levodopa-naïve patients with PD showed no COP-stabilizing synergy “off-drug”, whereas controls showed posture-stabilizing multi-M-mode synergy. “On-drug”, patients with PD demonstrated a significant increase in the synergy index. There were no significant drug effects on the M-mode composition, anticipatory postural adjustments, indices of motor equivalence, or indices of COP variability. The results suggest that levodopa-naïve patients with PD already show impaired posture-stabilizing multi-muscle synergies that may be used as promising behavioral biomarkers for emerging postural disorders in PD. Moreover, levodopa modified synergy metrics differently in these levodopa-naïve patients compared to a previous study of patients on chronic antiparkinsonian medications, suggesting different neurocircuitry involvement.
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影响因子：
2
作者：
de Freitas, Paulo B.;Freitas, Sandra M. S. F.;Latash, Mark L.
通讯作者：
Latash, Mark L.
影响因子：
2
作者：
Au, Wing-Lok;Lei, Ni;McKeown, Martin J.
通讯作者：
McKeown, Martin J.
影响因子：
2.4
作者：
Falaki, Ali;Huang, Xuemei;Latash, Mark L.
通讯作者：
Latash, Mark L.
影响因子：
8.6
作者：
Frenklach, Arma;Louie, Stephanie;Bronte-Stewart, Helen
通讯作者：
Bronte-Stewart, Helen
影响因子：
5.5
作者：
Ivanenko, YP;Poppele, RE;Lacquaniti, F
通讯作者：
Lacquaniti, F