Expression of hMTH1 in the hippocampi of control and Alzheimer's disease
Expression of hMTH1 in the hippocampi of control and Alzheimer's disease
复制标题
hMTH1在对照和阿尔茨海默病海马中的表达
作者：
A. Furuta;T. Iida;Y. Nakabeppu;T. Iwaki
氧化型嘌呤核苷三磷酸酶 hMTH1 对于防止氧化型嘌呤核苷三磷酸（例如 8-氧代-dGTP 和 2-羟基-dATP）引起的错误具有关键作用。我们研究了代表非神经系统疾病和阿尔茨海默病 (AD) 的人海马死后组织中 hMTH1 的免疫组织化学表达。在非神经系统受试者中，hMTH1 蛋白在 CA3 对应于苔藓纤维突触的透明层中富集。在 AD 受试者中，CA3 的突触免疫反应性显着降低，而内嗅皮层的突触免疫反应性往往增加。我们认为 hMTH1 的表达表明氧化应激的间接证据，并且其调节在 AD 中存在区域差异。
The oxidized purine nucleoside triphosphatase, hMTH1, has a critical role towards preventing errors caused by oxidized purine nucleoside triphosphates such as 8-oxo-dGTP and 2-hydroxy-dATP. We investigated the immunohistochemical expression of hMTH1 in human hippocampal postmortem tissues representing non-neurological disease and Alzheimer's disease (AD). In the non-neurological subjects the hMTH1 protein was enriched in the stratum lucidum at CA3 corresponding to mossy fiber synapses. In AD subjects, the synaptic immunoreactivities at CA3 were significantly decreased, whereas they tended to be increased at the entorhinal cortex. We suggest that the expression of hMTH1 indicates indirect evidence of oxidative stress and its regulation is regionally differentiated in AD.
影响因子：
3.7
作者：
Arnold, Steven E.;Hyman, Bradley T.;Van Hoesen, Gary W.
通讯作者：
Van Hoesen, Gary W.
超氧化物歧化酶在阿尔茨海默病和唐氏综合症新皮质和海马中的定位。
DOI：
--
发表时间：
1995
期刊：
The American journal of pathology.
影响因子：
--
作者：
Furuta,A;Price,DL;Pardo,CA;Troncoso,JC;Xu,ZS;Taniguchi,N;Martin,LJ
通讯作者：
Martin,LJ