Dental regenerative therapy targeting sphingosine-1-phosphate (S1P) signaling pathway in endodontics.
Dental regenerative therapy targeting sphingosine-1-phosphate (S1P) signaling pathway in endodontics.
复制标题
牙髓学中针对鞘鞘醇-1-磷酸（S1P）信号通路的牙齿再生治疗。
DOI：
10.1016/j.jdsr.2020.09.002
复制
发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Anan H
中科院分区：
文献类型：
--
作者：
Matsuzaki E;Minakami M;Matsumoto N;Anan H
根管治疗中牙本质牙髓复合体、牙骨质、牙周膜组织和牙槽骨再生治疗的建立将为牙齿的保存提供有价值的信息。众所周知，干细胞如诱导多能干细胞、胚胎干细胞和体干细胞的应用在再生医学中是有效的。在牙齿和牙周组织中存在许多体干细胞，包括牙髓干细胞、根尖乳头干细胞和牙周膜干细胞。特别地，一些研究已经报道了通过DPSCs移植的临床牙髓组织和牙槽骨的再生。然而，实际实施中的进一步科学问题仍有待解决。鞘氨醇-1-磷酸（S1 P）是一种具有生物活性的信号分子，具有多种生物学功能，包括细胞分化，并已被证明负责骨吸收和骨形成。在这里，我们讨论了骨再生的策略和再生牙髓治疗的可能性，靶向S1 P信号通路作为诱导再生的方法之一，通过提高内源性细胞的再生能力。牙髓病学
The establishment of regenerative therapy in endodontics targeting the dentin-pulp complex, cementum, periodontal ligament tissue, and alveolar bone will provide valuable information to preserve teeth. It is well known that the application of stem cells such as induced pluripotent stem cells, embryonic stem cells, and somatic stem cells is effective in regenerative medicine. There are many somatic stem cells in teeth and periodontal tissues including dental pulp stem cells (DPSCs), stem cells from the apical papilla, and periodontal ligament stem cells. Particularly, several studies have reported the regeneration of clinical pulp tissue and alveolar bone by DPSCs transplantation. However, further scientific issues for practical implementation remain to be addressed. Sphingosine-1-phosphate (S1P) acts as a bioactive signaling molecule that has multiple biological functions including cellular differentiation, and has been shown to be responsible for bone resorption and formation. Here we discuss a strategy for bone regeneration and a possibility for regenerative endodontics targeting S1P signaling pathway as one of approaches for induction of regeneration by improving the regenerative capacity of endogenous cells. Endodontology
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