Immunohistochemical study of hepatocyte, cholangiocyte and stem cell markers of hepatocellular carcinoma: the second report: relationship with tumor size and cell differentiation.
Immunohistochemical study of hepatocyte, cholangiocyte and stem cell markers of hepatocellular carcinoma: the second report: relationship with tumor size and cell differentiation.
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DOI：
10.1002/jhbp.356
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发表时间：
2016-07
影响因子：
3
通讯作者：
Fukusato, Toshio
中科院分区：
文献类型：
--
作者：
Kumagai, Arisa;Kondo, Fukuo;Sano, Keiji;Inoue, Masafumi;Fujii, Takeshi;Hashimoto, Masaji;Watanabe, Masato;Soejima, Yurie;Ishida, Tsuyoshi;Tokairin, Takuo;Saito, Koji;Sasajima, Yuko;Takahashi, Yoshihisa;Uozaki, Hiroshi;Fukusato, Toshio
本研究的目的是探讨普通型肝细胞癌（HCC）在肿瘤进展过程中是否表现出干/祖细胞标志物和胆管细胞标志物的阳性。使用两种肝细胞标志物（Hep par 1和甲胎蛋白）、五种胆管细胞标志物（细胞角蛋白CK 7、CK 19、Muc 1、上皮膜抗原和癌胚抗原）和三种肝干/祖细胞标志物（CD 56、c-Kit和EpCAM）对94例患者的94个不大于8 cm的HCC病灶进行免疫组织化学研究。根据肿瘤大小分为三组：S1，< 2.0 cm; S2，2.0-5.0 cm; S3，5.0-8.0 cm。还根据肿瘤分化将肿瘤分类：分化良好、中度和分化不良。分析这些标记物的阳性率与肿瘤大小和肿瘤分化程度的关系。胆管细胞标志物的阳性率在肿瘤较大和分化较低的患者中有增高的趋势（CK 7除外）。干/祖细胞标志物的阳性比率在较大尺寸和分化较低的肿瘤中倾向于较高（c-Kit除外）。在肿瘤进展过程中，普通型肝癌可获得胆管细胞和干/祖细胞标志物阳性的特征。
The purpose of this study is to investigate whether ordinary hepatocellular carcinomas (HCCs) show positivity of stem/progenitor cell markers and cholangiocyte markers during the process of tumor progression. Ninety‐four HCC lesions no larger than 8 cm from 94 patients were immuno‐histochemically studied using two hepatocyte markers (Hep par 1 and α‐fetoprotein), five cholangiocyte markers (cytokeratin CK7, CK19, Muc1, epithelial membrane antigen and carcinoembryonic antigen) and three hepatic stem/progenitor cell markers (CD56, c‐Kit and EpCAM). The tumors were classified into three groups by tumor size: S1, < 2.0 cm; S2, 2.0–5.0 cm; S3, 5.0–8.0 cm. The tumors were also classified according to tumor differentiation: well, moderately and poorly differentiated. The relationship between the positive ratios of these markers, tumor size and tumor differentiation was examined. The positive ratios of cholangiocyte markers tended to be higher in larger sized and more poorly differentiated tumors (except for CK7). The positive ratios of stem/progenitor cell markers tended to be higher in larger sized and more poorly differentiated tumors (except for c‐Kit). Ordinary HCC can acquire the characteristic of positivity of cholangiocyte and stem/progenitor cell markers during the process of tumor progression.
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影响因子：
3
作者：
Maeno, Sawako;Kondo, Fukuo;Sano, Keiji;Takada, Tadahiro;Asano, Takehide
通讯作者：
Asano, Takehide
影响因子：
15.9
作者：
Sekiya, Sayaka;Suzuki, Atsushi
通讯作者：
Suzuki, Atsushi
影响因子：
3.3
作者：
Aishima, S;Kuroda, Y;Tsuneyoshi, M
通讯作者：
Tsuneyoshi, M
影响因子：
5.6
作者：
Aishima, Shinichi;Nishihara, Yunosuke;Tsuneyoshi, Masazumi
通讯作者：
Tsuneyoshi, Masazumi
DOI：
10.1111/j.1440-1746.1996.tb00327.x
发表时间：
1996-08-01
影响因子：
4.1
作者：
Taguchi, J;Nakashima, O;Kojiro, M
通讯作者：
Kojiro, M