Detecting cocaine use through sweat testing: multilevel modeling of sweat patch length-of-wear data.

Detecting cocaine use through sweat testing: multilevel modeling of sweat patch length-of-wear data.
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通过汗水测试检测可卡因的使用:汗贴佩戴长度数据的多级建模。

DOI:
10.1093/jat/28.8.667
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发表时间:
2004
影响因子:
2.5
通讯作者:
Fortner,Neil
Fortner,Neil
中科院分区:
医学3区
文献类型:
--
作者:
Liberty,HilaryJames;Johnson,BruceD;Fortner,Neil

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虽然尿液分析仍然是检测滥用药物的标准,但汗片提供了一个方便的替代方案,可以避免药物测试的一些问题,如在观察到的尿液中侵犯隐私、疾病传播的可能性和有毒液体的运输。这项研究考察了检测最近或同时使用可卡因所需的最小磨损长度,以及随着长期磨损的增加,分析物浓度的差异。27名受试者(22名吸毒者和5名不吸毒的对照受试者)先短期(1小时、1小时、1小时、1小时和2小时),然后长期贴片(1天、3天、7天和14天)。除了磨损的持续时间外,短期和长期的补丁是相同的。发现的主要分析物是可卡因,其次是苯甲酰ecGonine,然后是ecGonine甲酯。在本样本中,必须佩戴贴片才能检测到最近或同时使用可卡因的最短持续时间超过2小时,并且小于或等于1天。随着磨损长度的增加,分析物浓度显著增加。然而,一周和两周贴片之间的增加只对苯甲酰ecGonine有显著影响。
Although urine analysis remains the standard for detection of drugs of abuse, sweat patches provide a convenient alternative that avoids some of the problems with drug testing such as violations of privacy in observed urination, possibility of disease transmission, and transport of noxious fluids. This study examined minimum length of wear necessary to detect recent or concurrent cocaine use in a convenience sample of active cocaine users and also differences in analyte concentrations with increasing longer-term wear. Twenty-seven subjects (22 active drug users and 5 comparison subjects who did not use drugs) wore short-term (½ h, 1 h, 1½ h, and 2 h), then long-term patches (1, 3, 7, and 14 day). Short- and long-term patches were identical except for duration of wear. The predominant analyte found was cocaine, followed by benzoylecgonine, then ecgonine methylester. The minimum duration that patches must be worn to detect recent or concurrent cocaine use in this sample is more than 2 h and less than or equal to 1 day. Analyte concentrations increase significantly with increasing lengths of wear. However, increases between the one-week and two-week patches were significant for benzoylecgonine only.
DOI: 10.1001/archpsyc.1993.01820210073009
发表时间: 1993
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DOI: --
发表时间: 1994
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发表时间: 2001-09-01
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DOI: --
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期刊: NIDA research monograph
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