Oocytes With Smooth Endoplasmic Reticulum Aggregates Are Not Associated With Impaired Reproductive Outcomes: A Matched Retrospective Cohort Study.
Oocytes With Smooth Endoplasmic Reticulum Aggregates Are Not Associated With Impaired Reproductive Outcomes: A Matched Retrospective Cohort Study.
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具有光滑内质网聚集体的卵母细胞与生殖结果受损无关：一项匹配的回顾性队列研究
DOI：
10.3389/fendo.2021.688967
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发表时间：
2021
影响因子：
5.2
通讯作者：
Sun L
中科院分区：
文献类型：
--
作者：
Xu J;Yang L;Chen ZH;Yin MN;Chen J;Sun L
研究光滑内质网聚集体（SERa）是否影响卵母细胞的生殖结果。2010年1月至2019年12月，我中心共进行了2893个卵胞浆内单精子注射（ICSI）周期。在43个移植周期中，移植胚胎全部来自SERa+卵母细胞。43个周期中的每个周期与来自SERa的单独对照受试者匹配-相同年龄（± 1岁）、胚胎状况、不孕症的主要原因、用于新鲜或冷冻胚胎移植周期的方案类型的患者。比较两组临床妊娠、着床、异位妊娠及活产率。将来自SERa-患者的43个胚胎移植周期与具有纯SERa+卵母细胞衍生的胚胎的43个移植周期匹配。SERa+卵母细胞组和匹配组之间的临床妊娠率（55.81% vs. 65.11%，p=0.5081）、种植率（47.89% vs. 50.70%，p=0.8667）和活产率（48.84% vs. 55.81%，p=0.6659）没有观察到显著差异。两组均未发现先天性出生缺陷。结果表明，含SERa的卵母细胞衍生胚胎的着床、临床妊娠、活产率和出生缺陷率均未受到影响。
To investigate whether the reproductive outcomes of oocytes with smooth endoplasmic reticulum aggregates (SERa) are impaired. A total of 2893 intracytoplasmic sperm injection (ICSI) cycles were performed between January 2010 and December 2019 in our center. In 43 transfer cycles, transferred embryos were totally derived from SERa+ oocytes. Each of the 43 cycles was matched with a separate control subject from SERa- patient of the same age ( ± 1 year), embryo condition, main causes of infertility, type of protocols used for fresh or frozen embryo transfer cycles. The clinical pregnancy, implantation, ectopic pregnancy and live birth rate were compared between the two groups. 43 embryo transfer cycles from SERa- patient were matched to the 43 transferred cycles with pure SERa+ oocytes derived embryos. No significant difference was observed in clinical pregnancy rate (55.81% vs. 65.11%, p=0.5081), implantation rate (47.89% vs. 50.70%, p=0.8667) and live birth rate (48.84% vs. 55.81%, p=0.6659) between the SERa+ oocyte group and the matched group. No congenital birth defects were found in the two groups. Our results suggest that the implantation, clinical pregnancy, live birth and birth defects rate of embryos derived from oocytes with SERa are not impaired.
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