Neuronally-enriched exosomal microRNA-27b mediates acute effects of ibuprofen on reward-related brain activity in healthy adults: a randomized, placebo-controlled, double-blind trial.
Neuronally-enriched exosomal microRNA-27b mediates acute effects of ibuprofen on reward-related brain activity in healthy adults: a randomized, placebo-controlled, double-blind trial.
复制标题
DOI：
10.1038/s41598-022-04875-y
复制
发表时间：
2022-01-17
影响因子：
4.6
通讯作者：
Paulus MP
中科院分区：
文献类型：
--
作者：
Burrows K;Figueroa-Hall LK;Kuplicki R;Stewart JL;Alarbi AM;Ramesh R;Savitz JB;Teague TK;Risbrough VB;Paulus MP
这种双盲、随机、受试者内设计评估了抗炎药物的急性给药是否会调节与奖励处理的宏观变化相关的神经元特异性、炎症调节 microRNA。 20 名健康受试者（10 名女性，10 名男性）在执行金钱激励延迟 (MID) 任务时接受了功能性磁共振成像扫描，并在服用安慰剂、200 毫克或 600 毫克布洛芬后提供了血液样本。从血清中提取富含神经元的外泌体 microRNA 并进行测序。结果显示：(1) 600 mg 布洛芬比安慰剂表现出更高的 miR-27b-3p、miR-320b、miR-23b 和 miR-203a-3p 表达； (2) 在 MID 丧失预期期间，较高的 mir-27b-3p 与较低的岛叶激活相关； (3) 安慰剂期间，miR-27b-3p 与双侧壳核 MID 增益预期之间存在负相关关系，200 毫克和 600 毫克布洛芬均减弱了这种模式。这些发现与 miR-27b 可能是一种重要的消息分子，与调节正价或负价信息的处理相关的假设是一致的。
This double-blind, randomized, within-subjects design evaluated whether acute administration of an anti-inflammatory drug modulates neuron-specific, inflammation-modulating microRNAs linked to macroscopic changes in reward processing. Twenty healthy subjects (10 females, 10 males) underwent a functional magnetic resonance imaging scan while performing a monetary incentive delay (MID) task and provided blood samples after administration of placebo, 200 mg, or 600 mg of ibuprofen. Neuronally-enriched exosomal microRNAs were extracted from serum and sequenced. Results showed that: (1) 600 mg of ibuprofen exhibited higher miR-27b-3p, miR-320b, miR-23b and miR-203a-3p expression than placebo; (2) higher mir-27b-3p was associated with lower insula activation during MID loss anticipation; and (3) there was an inverse relationship between miR-27b-3p and MID gain anticipation in bilateral putamen during placebo, a pattern attenuated by both 200 mg and 600 mg of ibuprofen. These findings are consistent with the hypothesis that miR-27b could be an important messaging molecule that is associated with regulating the processing of positive or negative valenced information.
登录
查看更多内容
影响因子：
25.8
作者：
Khandaker GM;Pearson RM;Zammit S;Lewis G;Jones PB
通讯作者：
Jones PB
影响因子：
5.3
作者：
Felger JC
通讯作者：
Felger JC
miR-320通过靶向adipoR1介导十二指肠空肠旁路术后糖尿病的改善
影响因子：
3.1
作者：
Guo Wei;Shao Yi;Hu Sanyuan
通讯作者：
Hu Sanyuan
影响因子：
1.8
作者：
Liu, Lu;Li, Xiaohua
通讯作者：
Li, Xiaohua
影响因子：
5.3
作者：
Brites D;Fernandes A
通讯作者：
Fernandes A