Development and validation of a measure of comprehension of genomic screening-negative results (CoG-NR).
Development and validation of a measure of comprehension of genomic screening-negative results (CoG-NR).
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DOI：
10.1038/s41431-020-0657-1
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Edwards TP
中科院分区：
文献类型：
--
作者：
Henderson GE;Ewing M;Kuczynski KJ;Cadigan RJ;Waltz M;Butterfield RM;Rini C;Weck K;Berg JS;Edwards TP
为了实现对罕见的医学上可行的疾病进行群体基因组筛查的希望，必须理解和克服返回正常/阴性结果的关键挑战。我们的研究目的是评估新的 13 项测量 (CoG-NR) 的功能，以了解和了解三种高度可行的疾病的正常/阴性基因组筛查结果：林奇综合征、遗传性乳腺癌和卵巢癌以及家族性高胆固醇血症。根据我们之前的研究和专家评审，我们开发了 CoG-NR，并在三项 Qualtrics 调查中使用假设场景测试了其功能。我们报告了其在三种不同条件下的心理测量特性和表现。该测量在三种条件下的表现相似。对项目难度、内部可靠性和差异项目功能的检查表明，这些项目表现良好，与基因组知识、健康素养和客观计算能力具有统计显着的正相关性。 CoG-NR 评估对每种情况的正常/阴性结果的理解。下一步是在实际接受过此类测试的个人中检查其性能，以及随后在临床或研究情况中的使用。 CoG-NR 测量作为一种工具，通过揭示对阴性结果的错误解释的普遍性，作为增强群体基因组筛查效益的工具，具有巨大的前景。
To realize the promise of population genomic screening for rare medically actionable conditions, critical challenges in the return of normal/negative results must be understood and overcome. Our study objective was to assess the functioning of a new 13-item measure (CoG-NR) of understanding of and knowledge about normal/negative genomic screening results for three highly actionable conditions: Lynch Syndrome, Hereditary Breast and Ovarian Cancer, and Familial Hypercholesterolemia. Based on our prior research and expert review, we developed CoG-NR and tested how well it functioned using hypothetical scenarios in three Qualtrics surveys. We report on its psychometric properties and performance across the three different conditions. The measure performed similarly for the three conditions. Examinations of item difficulty, internal reliability, and differential item functioning indicate that the items perform well, with statistically significant positive correlations with genomic knowledge, health literacy, and objective numeracy. CoG-NR assesses understanding of normal/negative results for each of the conditions. The next step is to examine its performance among individuals who have actually undergone such tests, and subsequent use in clinical or research situations. The CoG-NR measure holds great promise as a tool to enhance benefits of population genomic screening by bringing to light the prevalence of incorrect interpretation of negative results.
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影响因子：
--
作者：
Langer MM;Roche MI;Brewer NT;Berg JS;Khan CM;Leos C;Moore E;Brown M;Rini C
通讯作者：
Rini C
影响因子：
1.9
作者：
Nightingale, Brooke M.;Hovick, Shelly R.;Morales, Ana
通讯作者：
Morales, Ana
影响因子：
4.5
作者：
Osborne RH;Batterham RW;Elsworth GR;Hawkins M;Buchbinder R
通讯作者：
Buchbinder R
影响因子：
1.7
作者：
Guan, Yue;Condit, Celeste M.;McBride, Colleen M.
通讯作者：
McBride, Colleen M.
影响因子：
2
作者：
Michie, S;Smith, JA;Marteau, TM
通讯作者：
Marteau, TM